A database of hormones and their receptors |
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HMRbase accession number | 10007 |
Swiss-prot Accession number | Q9BQD1 (Sequence in FASTA format) |
Description | Pro-MCH-like protein 2 (Pro-melanin-concentrating hormone-like protein2). |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | N/A |
Developmental Stage | Not expressed during brain development. |
Similarity | Belongs to the melanin-concentrating hormone family. |
Tissue Specificity | Expressed in testis but not in brain |
Post translational modification | N/A |
Function | N/A |
Protein Length | 86 Amino acids |
Molecular weight | 9856 |
References | 1 PubMed abstract 11181993 2 PubMed abstract 8188237 3 PubMed abstract 11070051 |
Domain Name | Pro-MCH |
Hormone Name | Melanin-concentrating hormone-like |
Mature Hormone Sequence | DFDTLRCMLGRVYQRCWQV |
Position of mature hormone in Pre-Hormone protein | 19 Residues from position (68-86) |
Receptor | Q99705 Detail in HMRbase Q969V1 Detail in HMRbase |
Gene ID | N/A |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 10027 |
Swiss-prot Accession number | P01178 (Sequence in FASTA format) |
Description | Oxytocin-neurophysin 1 precursor (OT-NPI) [Contains: Oxytocin(Ocytocin); Neurophysin 1]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the vasopressin/oxytocin family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland |
Protein Length | 125 Amino acids |
Molecular weight | 12722 |
References | 1 PubMed abstract 3768139 2 PubMed abstract 2991279 3 Grunwald W.C. Jr., Cool D.R.; "Lack of sequence polymorphism in the oxytocin gene of autisticpatients."; Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases. 4 PubMed abstract 11780052 5 PubMed abstract 15489334 6 PubMed abstract 2249637 7 PubMed abstract 4065330 8 PubMed abstract 6574452 9 PubMed abstract 7262323 10 PubMed abstract 13591312 |
Domain Name | Hormone_5 |
Hormone Name | Oxytocin |
Mature Hormone Sequence | CYIQNCPLG |
Position of mature hormone in Pre-Hormone protein | 9 Residues from position (20-28) |
Receptor | P30559
Detail in HMRbase |
Gene ID | 5020 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 10102 |
Swiss-prot Accession number | Q14406 (Sequence in FASTA format) |
Description | Chorionic somatomammotropin hormone-like 1 precursor (Chorionicsomatomammotropin-like) (Lactogen-like). |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted protein |
Developmental Stage | N/A |
Similarity | Belongs to the somatotropin/prolactin family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | May be a novel gestational hormone required to compensate for absence of other members of the GH/CS cluster during gestation |
Protein Length | 199 Amino acids |
Molecular weight | 22649 |
References | 1 PubMed abstract 2744760 2 PubMed abstract 8083227 |
Domain Name | Hormone_1 |
Hormone Name | Chorionic somatomammotropin hormone-like 1 |
Mature Hormone Sequence | VQTVPLSRLFKEAMLQAHRAHQLAIDTYQEFISSWGMDSIPTSSNMEETQQKSNLELLHISLLLIESRLEPVRFLRSTFTNNLVYDTSDSDDYHLLKDLEEGIQMLMGRLEDGSHLTGQTLKQTYSKFDTNSHNHDALLKNYGLLHCFRKDMDKVETFLRMVQCRSVEGSCGF |
Position of mature hormone in Pre-Hormone protein | 173 Residues from position (27-199) |
Receptor | N/A |
Gene ID | 1444 |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Receptor for this Hormone are either unknown or have not yet been curated |
HMRbase accession number | 10305 |
Swiss-prot Accession number | P81277 (Sequence in FASTA format) |
Description | Prolactin-releasing peptide precursor (PrRP) (Prolactin-releasinghormone) [Contains: Prolactin-releasing peptide PrRP31; Prolactin-releasing peptide PrRP20]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted protein |
Developmental Stage | N/A |
Similarity | N/A |
Tissue Specificity | Medulla oblongata and hypothalamus |
Post translational modification | N/A |
Function | Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL |
Protein Length | 87 Amino acids |
Molecular weight | 9639 |
References | 1 PubMed abstract 9607765 2 PubMed abstract 15489334 3 PubMed abstract 10498338 |
Domain Name | N/A |
Hormone Name | Prolactin-releasing peptide PrRP31 |
Mature Hormone Sequence | SRTHRHSMEIRTPDINPAWYASRGIRPVGRF |
Position of mature hormone in Pre-Hormone protein | 31 Residues from position (23-53) |
Receptor | P49683
Detail in HMRbase |
Gene ID | 51052 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 10306 |
Swiss-prot Accession number | P81277 (Sequence in FASTA format) |
Description | Prolactin-releasing peptide precursor (PrRP) (Prolactin-releasinghormone) [Contains: Prolactin-releasing peptide PrRP31; Prolactin-releasing peptide PrRP20]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted protein |
Developmental Stage | N/A |
Similarity | N/A |
Tissue Specificity | Medulla oblongata and hypothalamus |
Post translational modification | N/A |
Function | Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL |
Protein Length | 87 Amino acids |
Molecular weight | 9639 |
References | 1 PubMed abstract 9607765 2 PubMed abstract 15489334 3 PubMed abstract 10498338 |
Domain Name | N/A |
Hormone Name | Prolactin-releasing peptide PrRP20 |
Mature Hormone Sequence | TPDINPAWYASRGIRPVGRF |
Position of mature hormone in Pre-Hormone protein | 20 Residues from position (34-53) |
Receptor | P49683
Detail in HMRbase |
Gene ID | 51052 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 10320 |
Swiss-prot Accession number | Q16048 (Sequence in FASTA format) |
Description | Pro-MCH-like protein 1 (Pro-melanin-concentrating hormone-like protein1) (Pro-MCH variant). |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | N/A |
Developmental Stage | Expressed in developing brain, found in fetal newborn and adult brain. |
Similarity | Belongs to the melanin-concentrating hormone family. |
Tissue Specificity | Expressed in testis and brain |
Post translational modification | N/A |
Function | N/A |
Protein Length | 86 Amino acids |
Molecular weight | 9715 |
References | 1 PubMed abstract 11181993 2 PubMed abstract 8326825 3 PubMed abstract 9729295 4 PubMed abstract 11070051 |
Domain Name | Pro-MCH |
Hormone Name | Melanin-concentrating hormone-like |
Mature Hormone Sequence | DFDTLSCMLGRVYQSCWQV |
Position of mature hormone in Pre-Hormone protein | 19 Residues from position (68-86) |
Receptor | Q99705 Detail in HMRbase Q969V1 Detail in HMRbase |
Gene ID | N/A |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 10331 |
Swiss-prot Accession number | Q6X4W1 (Sequence in FASTA format) |
Description | Nasal embryonic luteinizing hormone-releasing hormone factor (Nasalembryonic LHRH factor). |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Cell membrane; peripheral membrane protein (By similarity). Note=Found on the outside of the LHRH cell membrane and axons projecting from the olfactory pit and epithelium (By similarity) |
Developmental Stage | N/A |
Similarity | N/A |
Tissue Specificity | Highly expressed in adult and fetal brain, testis and kidney |
Post translational modification | N/A |
Function | Influences outgrowth of olfactory axons and migration of LHRH neurons |
Protein Length | 530 Amino acids |
Molecular weight | 60143 |
References | 1 PubMed abstract 15362570 2 PubMed abstract 14702039 3 PubMed abstract 15164053 4 PubMed abstract 15489334 5 Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases. 6 PubMed abstract 16565220 |
Domain Name | N/A |
Hormone Name | Nasal embryonic luteinizing hormone-releasing hormone factor |
Mature Hormone Sequence | MGAAASRRRALRSEAMSSVAAKVRAARAFGEYLSQSHPENRNGADHLLADAYSGHDGSPEMQPAPQNKRRLSLVSNGCYEGSLSEEPSIRKPAGEGPQPRVYTISGEPALLPSPEAEAIELAVVKGRRQRHPHHHSQPLRASPGGSREDVSRPCQSWAGSRQGSKECPGCAQLAPGPTPRAFGLDQPPLPETSGRRKKLERMYSVDRVSDDIPIRTWFPKENLFSFQTATTTMQAISVFRGYAERKRRKRENDSASVIQRNFRKHLRMVGSRRVKAQTFAERRERSFSRSWSDPTPMKADTSHDSRDSSDLQSSHCTLDEAFEDLDWDTEKGLEAVACDTEGFVPPKVMLISSKVPKAEYIPTIIRRDDPSIIPILYDHEHATFEDILEEIERKLNVYHKGAKIWKMLIFCQGGPGHLYLLKNKVATFAKVEKEEDMIHFWKRLSRLMSKVNPEPNVIHIMGCYILGNPNGEKLFQNLRTLMTPYRVTFESPLELSAQGKQMIETYFDFRLYRLWKSRQHSKLLDFDDVL |
Position of mature hormone in Pre-Hormone protein | 530 Residues from position (1-530) |
Receptor | P30968
Detail in HMRbase |
Gene ID | 26012 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 10338 |
Swiss-prot Accession number | Q8WXF3 (Sequence in FASTA format) |
Description | Relaxin-3 precursor (Prorelaxin H3) (Insulin-like peptide INSL7)(Insulin-like peptide 7) [Contains: Relaxin-3 B chain; Relaxin-3 Achain]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the insulin family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142). |
Protein Length | 142 Amino acids |
Molecular weight | 15451 |
References | 1 Holloway J.L., Lok S., Jaspers S.R.; "Homo sapiens insulin homolog polypeptide."; Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
2 PubMed abstract 12686464 3 PubMed abstract 12975309 4 PubMed abstract 12506116 5 PubMed abstract 14522968 6 PubMed abstract 14522967 |
Domain Name | N/A |
Hormone Name | Relaxin-3 B chain |
Mature Hormone Sequence | RAAPYGVRLCGREFIRAVIFTCGGSRW |
Position of mature hormone in Pre-Hormone protein | 27 Residues from position (26-52) |
Receptor | Q9NSD7 Detail in HMRbase Q8TDU9 Detail in HMRbase Q9HBX9 Detail in HMRbase Q8WXD0 Detail in HMRbase |
Gene ID | 117579 |
PDB ID | 2FHW |
Drugpedia | wiki |
Comments |
HMRbase accession number | 10339 |
Swiss-prot Accession number | Q8WXF3 (Sequence in FASTA format) |
Description | Relaxin-3 precursor (Prorelaxin H3) (Insulin-like peptide INSL7)(Insulin-like peptide 7) [Contains: Relaxin-3 B chain; Relaxin-3 Achain]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the insulin family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142). |
Protein Length | 142 Amino acids |
Molecular weight | 15451 |
References | 1 Holloway J.L., Lok S., Jaspers S.R.; "Homo sapiens insulin homolog polypeptide."; Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
2 PubMed abstract 12686464 3 PubMed abstract 12975309 4 PubMed abstract 12506116 5 PubMed abstract 14522968 6 PubMed abstract 14522967 |
Domain Name | N/A |
Hormone Name | Relaxin-3 A chain |
Mature Hormone Sequence | DVLAGLSSSCCKWGCSKSEISSLC |
Position of mature hormone in Pre-Hormone protein | 24 Residues from position (119-142) |
Receptor | Q9NSD7 Detail in HMRbase Q8TDU9 Detail in HMRbase Q9HBX9 Detail in HMRbase Q8WXD0 Detail in HMRbase |
Gene ID | 117579 |
PDB ID | 2FHW |
Drugpedia | wiki |
Comments |
HMRbase accession number | 10345 |
Swiss-prot Accession number | Q96T91 (Sequence in FASTA format) |
Description | Glycoprotein hormone alpha-2 precursor (Thyrostimulin subunit alpha). |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted protein |
Developmental Stage | N/A |
Similarity | Belongs to the glycoprotein hormones subunit alpha family. |
Tissue Specificity | Found in a variety of tissues |
Post translational modification | Glycosylated. |
Function | Stimulates the thyroid. Binds and activates THSR, leads to increased cAMP production |
Protein Length | 129 Amino acids |
Molecular weight | 14163 |
References | 1 Ching A., Gilbert T., Lok S., Sheppard P., Webster P., O'Hara P.J.; "A novel cysteine knot protein expressed in pancreatic acinar cells."; Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
2 PubMed abstract 15489334 3 PubMed abstract 12045258 4 PubMed abstract 12089349 |
Domain Name | N/A |
Hormone Name | Glycoprotein hormone alpha-2 |
Mature Hormone Sequence | QEAVIPGCHLHPFNVTVRSDRQGTCQGSHVAQACVGHCESSAFPSRYSVLVASGYRHNITSVSQCCTISGLKKVKVQLQCVGSRREELEIFTARACQCDMCRLSRY |
Position of mature hormone in Pre-Hormone protein | 106 Residues from position (24-129) |
Receptor | P16473
Detail in HMRbase |
Gene ID | 170589 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 10367 |
Swiss-prot Accession number | Q9UBU3 (Sequence in FASTA format) |
Description | Appetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide) (M46protein) [Contains: Ghrelin-27; Ghrelin-28 (Ghrelin); Obestatin]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted protein |
Developmental Stage | N/A |
Similarity | Belongs to the motilin family. |
Tissue Specificity | Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy |
Post translational modification | O-n-octanoylation is essential for ghrelin activity. The O-n- decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser- 26. A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with an unsaturated carboxylic acid. Amidation of Leu-98 is essential for obestatin activity (By similarity). |
Function | Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation |
Protein Length | 117 Amino acids |
Molecular weight | 12911 |
References | 1 PubMed abstract 10604470 2 PubMed abstract 10930375 3 Wajnrajch M.P., Ten I.S., Gertner J.M., Leibel R.L.; "Genomic organization of the human Ghrelin gene."; J. Endocr. Genet. 1:231-233(2000). 4 PubMed abstract 12414809 5 PubMed abstract 12975309 6 PubMed abstract 15489334 7 PubMed abstract 15340161 8 PubMed abstract 11306336 |
Domain Name | Motilin_assoc Motilin_ghrelin |
Hormone Name | Ghrelin-28 |
Mature Hormone Sequence | GSSFLSPEHQRVQQRKESKKPPAKLQPR |
Position of mature hormone in Pre-Hormone protein | 28 Residues from position (24-51) |
Receptor | Q02643
Detail in HMRbase |
Gene ID | 51738 |
PDB ID | 1P7X |
Drugpedia | wiki |
Comments |
HMRbase accession number | 10368 |
Swiss-prot Accession number | Q9UBU3 (Sequence in FASTA format) |
Description | Appetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide) (M46protein) [Contains: Ghrelin-27; Ghrelin-28 (Ghrelin); Obestatin]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted protein |
Developmental Stage | N/A |
Similarity | Belongs to the motilin family. |
Tissue Specificity | Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy |
Post translational modification | O-n-octanoylation is essential for ghrelin activity. The O-n- decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser- 26. A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with an unsaturated carboxylic acid. Amidation of Leu-98 is essential for obestatin activity (By similarity). |
Function | Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation |
Protein Length | 117 Amino acids |
Molecular weight | 12911 |
References | 1 PubMed abstract 10604470 2 PubMed abstract 10930375 3 Wajnrajch M.P., Ten I.S., Gertner J.M., Leibel R.L.; "Genomic organization of the human Ghrelin gene."; J. Endocr. Genet. 1:231-233(2000). 4 PubMed abstract 12414809 5 PubMed abstract 12975309 6 PubMed abstract 15489334 7 PubMed abstract 15340161 8 PubMed abstract 11306336 |
Domain Name | Motilin_assoc Motilin_ghrelin |
Hormone Name | Ghrelin-27 |
Mature Hormone Sequence | GSSFLSPEHQRVQQRKESKKPPAKLQP |
Position of mature hormone in Pre-Hormone protein | 27 Residues from position (24-50) |
Receptor | Q02643
Detail in HMRbase |
Gene ID | 51738 |
PDB ID | 1P7X |
Drugpedia | wiki |
Comments |
HMRbase accession number | 10369 |
Swiss-prot Accession number | Q9UBU3 (Sequence in FASTA format) |
Description | Appetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide) (M46protein) [Contains: Ghrelin-27; Ghrelin-28 (Ghrelin); Obestatin]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted protein |
Developmental Stage | N/A |
Similarity | Belongs to the motilin family. |
Tissue Specificity | Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy |
Post translational modification | O-n-octanoylation is essential for ghrelin activity. The O-n- decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser- 26. A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with an unsaturated carboxylic acid. Amidation of Leu-98 is essential for obestatin activity (By similarity). |
Function | Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility |
Protein Length | 117 Amino acids |
Molecular weight | 12911 |
References | 1 PubMed abstract 10604470 2 PubMed abstract 10930375 3 Wajnrajch M.P., Ten I.S., Gertner J.M., Leibel R.L.; "Genomic organization of the human Ghrelin gene."; J. Endocr. Genet. 1:231-233(2000). 4 PubMed abstract 12414809 5 PubMed abstract 12975309 6 PubMed abstract 15489334 7 PubMed abstract 15340161 8 PubMed abstract 11306336 |
Domain Name | Motilin_assoc Motilin_ghrelin |
Hormone Name | Obestatin |
Mature Hormone Sequence | FNAPFDVGIKLSGVQYQQHSQAL |
Position of mature hormone in Pre-Hormone protein | 23 Residues from position (76-98) |
Receptor | Q02643
Detail in HMRbase |
Gene ID | 51738 |
PDB ID | 1P7X |
Drugpedia | wiki |
Comments |
HMRbase accession number | 10595 |
Swiss-prot Accession number | P01243 (Sequence in FASTA format) |
Description | Chorionic somatomammotropin hormone precursor (Choriomammotropin)(Lactogen). |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted protein |
Developmental Stage | N/A |
Similarity | Belongs to the somatotropin/prolactin family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Similar to that of somatotropin |
Protein Length | 217 Amino acids |
Molecular weight | 25020 |
References | 1 PubMed abstract 6208192 2 PubMed abstract 3030680 3 PubMed abstract 6300056 4 PubMed abstract 2744760 5 PubMed abstract 7169009 6 Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 7 PubMed abstract 15489334 8 PubMed abstract 593368 9 PubMed abstract 4712450 10 PubMed abstract 5286363 11 Sherwood L.M., Handwerger S., McLaurin W.D., Lanner M.; Nature New Biol. 235:64-64(1972). 12 PubMed abstract 438159 |
Domain Name | Hormone_1 |
Hormone Name | Chorionic somatomammotropin hormone (Choriomammotropin) (Lactogen) |
Mature Hormone Sequence | VQTVPLSRLFDHAMLQAHRAHQLAIDTYQEFEETYIPKDQKYSFLHDSQTSFCFSDSIPTPSNMEETQQKSNLELLRISLLLIESWLEPVRFLRSMFANNLVYDTSDSDDYHLLKDLEEGIQTLMGRLEDGSRRTGQILKQTYSKFDTNSHNHDALLKNYGLLYCFRKDMDKVETFLRMVQCRSVEGSCGF |
Position of mature hormone in Pre-Hormone protein | 191 Residues from position (27-217) |
Receptor | N/A |
Gene ID | 1442 |
PDB ID | 1Z7C |
Drugpedia | wiki |
Comments | !Receptor for this Hormone are either unknown or have not yet been curated |
HMRbase accession number | 10681 |
Swiss-prot Accession number | P01298 (Sequence in FASTA format) |
Description | Pancreatic prohormone precursor (Pancreatic polypeptide) (PP)[Contains: Pancreatic hormone; Pancreatic icosapeptide]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted protein |
Developmental Stage | N/A |
Similarity | Belongs to the NPY family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions |
Protein Length | 95 Amino acids |
Molecular weight | 10445 |
References | 1 PubMed abstract 6373251 2 PubMed abstract 2997153 3 PubMed abstract 6094571 4 PubMed abstract 3753985 5 PubMed abstract 15489334 6 PubMed abstract 6366786 7 PubMed abstract 15966750 |
Domain Name | Hormone_3 |
Hormone Name | Pancreatic hormone |
Mature Hormone Sequence | APLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRY |
Position of mature hormone in Pre-Hormone protein | 36 Residues from position (30-65) |
Receptor | N/A |
Gene ID | 5539 |
PDB ID | 1TZ4 1TZ5 |
Drugpedia | wiki |
Comments | !Receptor for this Hormone are either unknown or have not yet been curated |
HMRbase accession number | 10682 |
Swiss-prot Accession number | P01298 (Sequence in FASTA format) |
Description | Pancreatic prohormone precursor (Pancreatic polypeptide) (PP)[Contains: Pancreatic hormone; Pancreatic icosapeptide]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted protein |
Developmental Stage | N/A |
Similarity | Belongs to the NPY family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | The physiological role for the icosapeptide has not yet been elucidated |
Protein Length | 95 Amino acids |
Molecular weight | 10445 |
References | 1 PubMed abstract 6373251 2 PubMed abstract 2997153 3 PubMed abstract 6094571 4 PubMed abstract 3753985 5 PubMed abstract 15489334 6 PubMed abstract 6366786 7 PubMed abstract 15966750 |
Domain Name | Hormone_3 |
Hormone Name | Pancreatic icosapeptide |
Mature Hormone Sequence | HKEDTLAFSEWGSPHAAVPR |
Position of mature hormone in Pre-Hormone protein | 20 Residues from position (69-88) |
Receptor | N/A |
Gene ID | 5539 |
PDB ID | 1TZ4 1TZ5 |
Drugpedia | wiki |
Comments | !Receptor for this Hormone are either unknown or have not yet been curated |
HMRbase accession number | 10708 |
Swiss-prot Accession number | P01242 (Sequence in FASTA format) |
Description | Growth hormone variant precursor (GH-V) (Placenta-specific growthhormone) (Growth hormone 2). |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted protein |
Developmental Stage | N/A |
Similarity | Belongs to the somatotropin/prolactin family. |
Tissue Specificity | Expressed in the placenta |
Post translational modification | N/A |
Function | Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues |
Protein Length | 217 Amino acids |
Molecular weight | 25000 |
References | 1 PubMed abstract 7169009 2 PubMed abstract 3379057 3 PubMed abstract 2460050 4 PubMed abstract 2744760 5 PubMed abstract 15489334 6 PubMed abstract 2196278 7 PubMed abstract 10393484 |
Domain Name | Hormone_1 |
Hormone Name | Growth hormone 2 (Placenta-specific growth hormone) (GH-V) |
Mature Hormone Sequence | FPTIPLSRLFDNAMLRARRLYQLAYDTYQEFEEAYILKEQKYSFLQNPQTSLCFSESIPTPSNRVKTQQKSNLELLRISLLLIQSWLEPVQLLRSVFANSLVYGASDSNVYRHLKDLEEGIQTLMWRLEDGSPRTGQIFNQSYSKFDTKSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF |
Position of mature hormone in Pre-Hormone protein | 191 Residues from position (27-217) |
Receptor | N/A |
Gene ID | 2689 |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Receptor for this Hormone are either unknown or have not yet been curated |
HMRbase accession number | 11039 |
Swiss-prot Accession number | P06454 (Sequence in FASTA format) |
Description | Prothymosin alpha [Contains: Thymosin alpha-1]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Nucleus |
Developmental Stage | N/A |
Similarity | Belongs to the pro/parathymosin family. |
Tissue Specificity | N/A |
Post translational modification | Covalently linked to a small RNA of about 20 nucleotides (By similarity). |
Function | Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections |
Protein Length | 111 Amino acids |
Molecular weight | 12203 |
References | 1 PubMed abstract 3467312 2 PubMed abstract 3466166 3 PubMed abstract 2708378 4 PubMed abstract 2785990 5 Li Z., Fan Q., Huang W., An L.; "A novel prothymosin alpha cDNA from thymus."; Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases. 6 PubMed abstract 15489334 7 PubMed abstract 7916742 8 PubMed abstract 3532956 9 PubMed abstract 8485135 10 PubMed abstract 17081983 |
Domain Name | Prothymosin |
Hormone Name | Prothymosin alpha |
Mature Hormone Sequence | SDAAVDTSSEITTKDLKEKKEVVEEAENGRDAPANGNAENEENGEQEADNEVDEEEEEGGEEEEEEEEGDGEEEDGDEDEEAESATGKRAAEDDEDDDVDTKKQKTDEDD |
Position of mature hormone in Pre-Hormone protein | 110 Residues from position (2-111) |
Receptor | N/A |
Gene ID | 5757 |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Receptor for this Hormone are either unknown or have not yet been curated |
HMRbase accession number | 11040 |
Swiss-prot Accession number | P06454 (Sequence in FASTA format) |
Description | Prothymosin alpha [Contains: Thymosin alpha-1]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Nucleus |
Developmental Stage | N/A |
Similarity | Belongs to the pro/parathymosin family. |
Tissue Specificity | N/A |
Post translational modification | Covalently linked to a small RNA of about 20 nucleotides (By similarity). |
Function | Thymosin alpha1 (Talpha1) is an oligopeptide hormone originally isolated from the thymus gland, and has been reported to have stimulating effects on the differentiation of T cells and NK cells |
Protein Length | 111 Amino acids |
Molecular weight | 12203 |
References | 1 PubMed abstract 3467312 2 PubMed abstract 3466166 3 PubMed abstract 2708378 4 PubMed abstract 2785990 5 Li Z., Fan Q., Huang W., An L.; "A novel prothymosin alpha cDNA from thymus."; Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases. 6 PubMed abstract 15489334 7 PubMed abstract 7916742 8 PubMed abstract 3532956 9 PubMed abstract 8485135 10 PubMed abstract 17081983 |
Domain Name | Prothymosin |
Hormone Name | Thymosin alpha-1 |
Mature Hormone Sequence | SDAAVDTSSEITTKDLKEKKEVVEEAEN |
Position of mature hormone in Pre-Hormone protein | 28 Residues from position (2-29) |
Receptor | N/A |
Gene ID | 5757 |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Receptor for this Hormone are either unknown or have not yet been curated |
HMRbase accession number | 11048 |
Swiss-prot Accession number | P63313 (Sequence in FASTA format) |
Description | Thymosin beta-10. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Cytoplasm |
Developmental Stage | Found to decrease dramatically after birth. |
Similarity | Belongs to the thymosin beta family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization |
Protein Length | 44 Amino acids |
Molecular weight | 5026 |
References | 1 PubMed abstract 3365256 2 PubMed abstract 2169566 3 PubMed abstract 8425765 4 Condon M.R., Hall A.K.; "Human thymosin beta 10 gene: its characterization and nucleotidesequence."; Submitted (APR-1992) to the EMBL/GenBank/DDBJ databases. 5 PubMed abstract 15489334 6 PubMed abstract 16916647 |
Domain Name | Thymosin |
Hormone Name | Thymosin beta-10 |
Mature Hormone Sequence | ADKPDMGEIASFDKAKLKKTETQEKNTLPTKETIEQEKRSEIS |
Position of mature hormone in Pre-Hormone protein | 43 Residues from position (2-44) |
Receptor | N/A |
Gene ID | 9168 |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Receptor for this Hormone are either unknown or have not yet been curated |
HMRbase accession number | 11054 |
Swiss-prot Accession number | O14604 (Sequence in FASTA format) |
Description | Thymosin beta-4, Y-chromosomal. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Cytoplasm (By similarity) |
Developmental Stage | N/A |
Similarity | Belongs to the thymosin beta family. |
Tissue Specificity | Ubiquitous |
Post translational modification | N/A |
Function | Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization |
Protein Length | 44 Amino acids |
Molecular weight | 5013 |
References | 1 PubMed abstract 9381176 2 PubMed abstract 12815422 3 PubMed abstract 15489334 |
Domain Name | Thymosin |
Hormone Name | Thymosin beta-4 |
Mature Hormone Sequence | SDKPGMAEIEKFDKSKLKKTETQEKNPLSSKETIEQERQAGES |
Position of mature hormone in Pre-Hormone protein | 43 Residues from position (2-44) |
Receptor | N/A |
Gene ID | 100130227 9087 |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Receptor for this Hormone are either unknown or have not yet been curated |
HMRbase accession number | 11059 |
Swiss-prot Accession number | P62328 (Sequence in FASTA format) |
Description | Thymosin beta-4 (T beta 4) (Fx) [Contains: Hematopoietic systemregulatory peptide (Seraspenide)]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Cytoplasm |
Developmental Stage | N/A |
Similarity | Belongs to the thymosin beta family. |
Tissue Specificity | Expressed in several hemopoietic cell lines and lymphoid malignant cells. Decreased levels in myeloma cells |
Post translational modification | N/A |
Function | Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization |
Protein Length | 44 Amino acids |
Molecular weight | 5053 |
References | 1 PubMed abstract 3500230 2 PubMed abstract 16010977 3 Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 4 PubMed abstract 1999398 5 PubMed abstract 6548414 6 PubMed abstract 10848969 |
Domain Name | Thymosin |
Hormone Name | Thymosin beta-4 |
Mature Hormone Sequence | SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES |
Position of mature hormone in Pre-Hormone protein | 43 Residues from position (2-44) |
Receptor | N/A |
Gene ID | 7114 |
PDB ID | 1UY5 |
Drugpedia | wiki |
Comments | !Receptor for this Hormone are either unknown or have not yet been curated |
HMRbase accession number | 11060 |
Swiss-prot Accession number | P62328 (Sequence in FASTA format) |
Description | Thymosin beta-4 (T beta 4) (Fx) [Contains: Hematopoietic systemregulatory peptide (Seraspenide)]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Cytoplasm |
Developmental Stage | N/A |
Similarity | Belongs to the thymosin beta family. |
Tissue Specificity | Expressed in several hemopoietic cell lines and lymphoid malignant cells. Decreased levels in myeloma cells |
Post translational modification | N/A |
Function | Seraspenide inhibits the entry of hematopoeitic pluripotent stem cells into the S-phase |
Protein Length | 44 Amino acids |
Molecular weight | 5053 |
References | 1 PubMed abstract 3500230 2 PubMed abstract 16010977 3 Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 4 PubMed abstract 1999398 5 PubMed abstract 6548414 6 PubMed abstract 10848969 |
Domain Name | Thymosin |
Hormone Name | Hematopoietic system regulatory peptide |
Mature Hormone Sequence | SDKP |
Position of mature hormone in Pre-Hormone protein | 4 Residues from position (2-5) |
Receptor | N/A |
Gene ID | 7114 |
PDB ID | 1UY5 |
Drugpedia | wiki |
Comments | !Receptor for this Hormone are either unknown or have not yet been curated |
HMRbase accession number | 11173 |
Swiss-prot Accession number | P06307 (Sequence in FASTA format) |
Description | Cholecystokinins precursor (CCK) [Contains: Cholecystokinin 58(CCK58); Cholecystokinin 39 (CCK39); Cholecystokinin 33 (CCK33);Cholecystokinin 12 (CCK12); Cholecystokinin 8 (CCK8)]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the gastrin/cholecystokinin family. |
Tissue Specificity | N/A |
Post translational modification | The precursor cleaved by enzymes to produce a number of active cholecystokinins. |
Function | This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion |
Protein Length | 115 Amino acids |
Molecular weight | 12669 |
References | 1 PubMed abstract 3856870 2 Kato K., Takahashi Y., Matsubara K.; "Molecular cloning of the human cholecystokinin gene."; Ann. N. Y. Acad. Sci. 448:613-615(1985). 3 Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 4 Livingston R.J., Rieder M.J., Chung M.-W., Ritchie T.K., Olson A.N.,Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D., Schackwitz W.S.,Sherwood J.K., Sherwood A.M., Leithauser B.J., Nickerson D.A.; "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Departmentof Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)."; Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. 5 PubMed abstract 15489334 6 PubMed abstract 11076522 |
Domain Name | Gastrin |
Hormone Name | Cholecystokinin-12 |
Mature Hormone Sequence | ISDRDYMGWMDF |
Position of mature hormone in Pre-Hormone protein | 12 Residues from position (92-103) |
Receptor | P32239 Detail in HMRbase P32238 Detail in HMRbase |
Gene ID | 885 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11197 |
Swiss-prot Accession number | P09681 (Sequence in FASTA format) |
Description | Gastric inhibitory polypeptide precursor (GIP) (Glucose-dependentinsulinotropic polypeptide). |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the glucagon family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion |
Protein Length | 153 Amino acids |
Molecular weight | 17108 |
References | 1 PubMed abstract 2890159 2 PubMed abstract 2739653 3 PubMed abstract 15489334 4 PubMed abstract 6745415 5 PubMed abstract 15522230 |
Domain Name | Hormone_2 |
Hormone Name | Gastric inhibitory polypeptide |
Mature Hormone Sequence | YAEGTFISDYSIAMDKIHQQDFVNWLLAQKGKKNDWKHNITQ |
Position of mature hormone in Pre-Hormone protein | 42 Residues from position (52-93) |
Receptor | N/A |
Gene ID | 2695 |
PDB ID | 1T5Q 2B4N |
Drugpedia | wiki |
Comments | !Receptor for this Hormone are either unknown or have not yet been curated |
HMRbase accession number | 11235 |
Swiss-prot Accession number | O43555 (Sequence in FASTA format) |
Description | Progonadoliberin-2 precursor (Progonadoliberin II) [Contains:Gonadoliberin-2 (Gonadoliberin II) (Luteinizing hormone-releasinghormone II) (LH-RH II) (Gonadotropin-releasing hormone II) (GnRH II)(Luliberin II); GnRH-associated peptide 2 (GnRH-associated peptideII)]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted protein |
Developmental Stage | N/A |
Similarity | Belongs to the GnRH family. |
Tissue Specificity | Midbrain; expressed at significantly higher levels outside the brain (up to 30-fold), particularly in the kidney, bone marrow and prostate |
Post translational modification | N/A |
Function | Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones |
Protein Length | 120 Amino acids |
Molecular weight | 12918 |
References | 1 PubMed abstract 9419371 2 PubMed abstract 11780052 3 PubMed abstract 15489334 |
Domain Name | N/A |
Hormone Name | Gonadoliberin-2 |
Mature Hormone Sequence | QHWSHGWYPG |
Position of mature hormone in Pre-Hormone protein | 10 Residues from position (24-33) |
Receptor | P30968 Detail in HMRbase Q96P88 Detail in HMRbase |
Gene ID | 2797 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11243 |
Swiss-prot Accession number | P01148 (Sequence in FASTA format) |
Description | Progonadoliberin-1 precursor (Progonadoliberin I) [Contains:Gonadoliberin-1 (Gonadoliberin I) (Luteinizing hormone-releasinghormone I) (LH-RH I) (Gonadotropin-releasing hormone I) (GnRH-I)(Luliberin I) (Gonadorelin); GnRH-associated peptide 1 (GnRH-associated peptide I)]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted protein |
Developmental Stage | N/A |
Similarity | Belongs to the GnRH family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones |
Protein Length | 92 Amino acids |
Molecular weight | 10380 |
References | 1 PubMed abstract 2671939 2 PubMed abstract 2867548 3 PubMed abstract 6090951 4 PubMed abstract 15489334 5 PubMed abstract 6760865 6 PubMed abstract 10391209 7 Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N.,Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L.,Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q.,Lander E.S.; Nat. Genet. 23:373-373(1999). |
Domain Name | N/A |
Hormone Name | Gonadoliberin-1 |
Mature Hormone Sequence | QHWSYGLRPG |
Position of mature hormone in Pre-Hormone protein | 10 Residues from position (24-33) |
Receptor | P30968
Detail in HMRbase |
Gene ID | 2796 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11250 |
Swiss-prot Accession number | P01189 (Sequence in FASTA format) |
Description | Corticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Contains: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide;Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanotropin alpha(Alpha-MSH); Corticotropin-like intermediary peptide (CLIP);Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropinbeta (Beta-MSH); Beta-endorphin; Met-enkephalin]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | N/A |
Developmental Stage | N/A |
Similarity | Belongs to the POMC family. |
Tissue Specificity | ACTH and MSH are produced by the pituitary gland |
Post translational modification | Specific enzymatic cleavages at paired basic residues yield the different active peptides. O-glycosylated; reducing sugar is probably N- acetylgalactosamine. |
Function | MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes |
Protein Length | 267 Amino acids |
Molecular weight | 29424 |
References | 1 PubMed abstract 6274691 2 PubMed abstract 6299668 3 PubMed abstract 6314261 4 PubMed abstract 15489334 5 PubMed abstract 3606677 6 PubMed abstract 6254047 7 PubMed abstract 6945581 8 PubMed abstract 6267033 9 PubMed abstract 6272808 10 PubMed abstract 4352834 11 PubMed abstract 14463577 12 PubMed abstract 15340161 13 PubMed abstract 4334191 14 PubMed abstract 4338630 15 PubMed abstract 4347148 16 PubMed abstract 1264228 17 Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 18 PubMed abstract 195688 19 PubMed abstract 2424570 20 PubMed abstract 2839146 21 PubMed abstract 7828531 22 PubMed abstract 9620771 23 PubMed abstract 16046320 24 PubMed abstract 16807684 25 PubMed abstract 9768693 26 PubMed abstract 10193875 27 PubMed abstract 11244459 28 PubMed abstract 12165561 29 PubMed abstract 6274691 30 PubMed abstract 6299668 31 PubMed abstract 6314261 32 PubMed abstract 15489334 33 PubMed abstract 3606677 34 PubMed abstract 6254047 35 PubMed abstract 6945581 36 PubMed abstract 6267033 37 PubMed abstract 6272808 38 PubMed abstract 4352834 39 PubMed abstract 14463577 40 PubMed abstract 15340161 41 PubMed abstract 4334191 42 PubMed abstract 4338630 43 PubMed abstract 4347148 44 PubMed abstract 1264228 45 Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 46 PubMed abstract 195688 47 PubMed abstract 2424570 48 PubMed abstract 2839146 49 PubMed abstract 7828531 50 PubMed abstract 9620771 51 PubMed abstract 16046320 52 PubMed abstract 16807684 53 PubMed abstract 9768693 54 PubMed abstract 10193875 55 PubMed abstract 11244459 56 PubMed abstract 12165561 |
Domain Name | ACTH_domain NPP Op_neuropeptide |
Hormone Name | Melanotropin gamma (Gamma-MSH) |
Mature Hormone Sequence | YVMGHFRWDRF |
Position of mature hormone in Pre-Hormone protein | 11 Residues from position (77-87) |
Receptor | Q01726
Detail in HMRbase |
Gene ID | 5443 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11251 |
Swiss-prot Accession number | P01189 (Sequence in FASTA format) |
Description | Corticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Contains: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide;Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanotropin alpha(Alpha-MSH); Corticotropin-like intermediary peptide (CLIP);Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropinbeta (Beta-MSH); Beta-endorphin; Met-enkephalin]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | N/A |
Developmental Stage | N/A |
Similarity | Belongs to the POMC family. |
Tissue Specificity | ACTH and MSH are produced by the pituitary gland |
Post translational modification | Specific enzymatic cleavages at paired basic residues yield the different active peptides. O-glycosylated; reducing sugar is probably N- acetylgalactosamine. |
Function | ACTH stimulates the adrenal glands to release cortisol |
Protein Length | 267 Amino acids |
Molecular weight | 29424 |
References | 1 PubMed abstract 6274691 2 PubMed abstract 6299668 3 PubMed abstract 6314261 4 PubMed abstract 15489334 5 PubMed abstract 3606677 6 PubMed abstract 6254047 7 PubMed abstract 6945581 8 PubMed abstract 6267033 9 PubMed abstract 6272808 10 PubMed abstract 4352834 11 PubMed abstract 14463577 12 PubMed abstract 15340161 13 PubMed abstract 4334191 14 PubMed abstract 4338630 15 PubMed abstract 4347148 16 PubMed abstract 1264228 17 Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 18 PubMed abstract 195688 19 PubMed abstract 2424570 20 PubMed abstract 2839146 21 PubMed abstract 7828531 22 PubMed abstract 9620771 23 PubMed abstract 16046320 24 PubMed abstract 16807684 25 PubMed abstract 9768693 26 PubMed abstract 10193875 27 PubMed abstract 11244459 28 PubMed abstract 12165561 29 PubMed abstract 6274691 30 PubMed abstract 6299668 31 PubMed abstract 6314261 32 PubMed abstract 15489334 33 PubMed abstract 3606677 34 PubMed abstract 6254047 35 PubMed abstract 6945581 36 PubMed abstract 6267033 37 PubMed abstract 6272808 38 PubMed abstract 4352834 39 PubMed abstract 14463577 40 PubMed abstract 15340161 41 PubMed abstract 4334191 42 PubMed abstract 4338630 43 PubMed abstract 4347148 44 PubMed abstract 1264228 45 Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 46 PubMed abstract 195688 47 PubMed abstract 2424570 48 PubMed abstract 2839146 49 PubMed abstract 7828531 50 PubMed abstract 9620771 51 PubMed abstract 16046320 52 PubMed abstract 16807684 53 PubMed abstract 9768693 54 PubMed abstract 10193875 55 PubMed abstract 11244459 56 PubMed abstract 12165561 |
Domain Name | ACTH_domain NPP Op_neuropeptide |
Hormone Name | Corticotropin |
Mature Hormone Sequence | SYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEF |
Position of mature hormone in Pre-Hormone protein | 39 Residues from position (138-176) |
Receptor | Q01726
Detail in HMRbase |
Gene ID | 5443 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11252 |
Swiss-prot Accession number | P01189 (Sequence in FASTA format) |
Description | Corticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Contains: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide;Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanotropin alpha(Alpha-MSH); Corticotropin-like intermediary peptide (CLIP);Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropinbeta (Beta-MSH); Beta-endorphin; Met-enkephalin]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | N/A |
Developmental Stage | N/A |
Similarity | Belongs to the POMC family. |
Tissue Specificity | ACTH and MSH are produced by the pituitary gland |
Post translational modification | Specific enzymatic cleavages at paired basic residues yield the different active peptides. O-glycosylated; reducing sugar is probably N- acetylgalactosamine. |
Function | MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes |
Protein Length | 267 Amino acids |
Molecular weight | 29424 |
References | 1 PubMed abstract 6274691 2 PubMed abstract 6299668 3 PubMed abstract 6314261 4 PubMed abstract 15489334 5 PubMed abstract 3606677 6 PubMed abstract 6254047 7 PubMed abstract 6945581 8 PubMed abstract 6267033 9 PubMed abstract 6272808 10 PubMed abstract 4352834 11 PubMed abstract 14463577 12 PubMed abstract 15340161 13 PubMed abstract 4334191 14 PubMed abstract 4338630 15 PubMed abstract 4347148 16 PubMed abstract 1264228 17 Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 18 PubMed abstract 195688 19 PubMed abstract 2424570 20 PubMed abstract 2839146 21 PubMed abstract 7828531 22 PubMed abstract 9620771 23 PubMed abstract 16046320 24 PubMed abstract 16807684 25 PubMed abstract 9768693 26 PubMed abstract 10193875 27 PubMed abstract 11244459 28 PubMed abstract 12165561 29 PubMed abstract 6274691 30 PubMed abstract 6299668 31 PubMed abstract 6314261 32 PubMed abstract 15489334 33 PubMed abstract 3606677 34 PubMed abstract 6254047 35 PubMed abstract 6945581 36 PubMed abstract 6267033 37 PubMed abstract 6272808 38 PubMed abstract 4352834 39 PubMed abstract 14463577 40 PubMed abstract 15340161 41 PubMed abstract 4334191 42 PubMed abstract 4338630 43 PubMed abstract 4347148 44 PubMed abstract 1264228 45 Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 46 PubMed abstract 195688 47 PubMed abstract 2424570 48 PubMed abstract 2839146 49 PubMed abstract 7828531 50 PubMed abstract 9620771 51 PubMed abstract 16046320 52 PubMed abstract 16807684 53 PubMed abstract 9768693 54 PubMed abstract 10193875 55 PubMed abstract 11244459 56 PubMed abstract 12165561 |
Domain Name | ACTH_domain NPP Op_neuropeptide |
Hormone Name | Melanotropin alpha (Alpha-MSH) |
Mature Hormone Sequence | SYSMEHFRWGKPV |
Position of mature hormone in Pre-Hormone protein | 13 Residues from position (138-150) |
Receptor | Q01726
Detail in HMRbase |
Gene ID | 5443 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11253 |
Swiss-prot Accession number | P01189 (Sequence in FASTA format) |
Description | Corticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Contains: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide;Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanotropin alpha(Alpha-MSH); Corticotropin-like intermediary peptide (CLIP);Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropinbeta (Beta-MSH); Beta-endorphin; Met-enkephalin]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | N/A |
Developmental Stage | N/A |
Similarity | Belongs to the POMC family. |
Tissue Specificity | ACTH and MSH are produced by the pituitary gland |
Post translational modification | Specific enzymatic cleavages at paired basic residues yield the different active peptides. O-glycosylated; reducing sugar is probably N- acetylgalactosamine. |
Function | Stimulates melanocytes to produce melanin. It performs lipid-mobilizing functions such as lipolysis and steroidogenesis. |
Protein Length | 267 Amino acids |
Molecular weight | 29424 |
References | 1 PubMed abstract 6274691 2 PubMed abstract 6299668 3 PubMed abstract 6314261 4 PubMed abstract 15489334 5 PubMed abstract 3606677 6 PubMed abstract 6254047 7 PubMed abstract 6945581 8 PubMed abstract 6267033 9 PubMed abstract 6272808 10 PubMed abstract 4352834 11 PubMed abstract 14463577 12 PubMed abstract 15340161 13 PubMed abstract 4334191 14 PubMed abstract 4338630 15 PubMed abstract 4347148 16 PubMed abstract 1264228 17 Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 18 PubMed abstract 195688 19 PubMed abstract 2424570 20 PubMed abstract 2839146 21 PubMed abstract 7828531 22 PubMed abstract 9620771 23 PubMed abstract 16046320 24 PubMed abstract 16807684 25 PubMed abstract 9768693 26 PubMed abstract 10193875 27 PubMed abstract 11244459 28 PubMed abstract 12165561 29 PubMed abstract 6274691 30 PubMed abstract 6299668 31 PubMed abstract 6314261 32 PubMed abstract 15489334 33 PubMed abstract 3606677 34 PubMed abstract 6254047 35 PubMed abstract 6945581 36 PubMed abstract 6267033 37 PubMed abstract 6272808 38 PubMed abstract 4352834 39 PubMed abstract 14463577 40 PubMed abstract 15340161 41 PubMed abstract 4334191 42 PubMed abstract 4338630 43 PubMed abstract 4347148 44 PubMed abstract 1264228 45 Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 46 PubMed abstract 195688 47 PubMed abstract 2424570 48 PubMed abstract 2839146 49 PubMed abstract 7828531 50 PubMed abstract 9620771 51 PubMed abstract 16046320 52 PubMed abstract 16807684 53 PubMed abstract 9768693 54 PubMed abstract 10193875 55 PubMed abstract 11244459 56 PubMed abstract 12165561 |
Domain Name | ACTH_domain NPP Op_neuropeptide |
Hormone Name | Lipotropin beta (Beta-LPH) |
Mature Hormone Sequence | ELTGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAYKKGE |
Position of mature hormone in Pre-Hormone protein | 89 Residues from position (179-267) |
Receptor | Q01726
Detail in HMRbase |
Gene ID | 5443 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11254 |
Swiss-prot Accession number | P01189 (Sequence in FASTA format) |
Description | Corticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Contains: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide;Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanotropin alpha(Alpha-MSH); Corticotropin-like intermediary peptide (CLIP);Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropinbeta (Beta-MSH); Beta-endorphin; Met-enkephalin]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | N/A |
Developmental Stage | N/A |
Similarity | Belongs to the POMC family. |
Tissue Specificity | ACTH and MSH are produced by the pituitary gland |
Post translational modification | Specific enzymatic cleavages at paired basic residues yield the different active peptides. O-glycosylated; reducing sugar is probably N- acetylgalactosamine. |
Function | Stimulates melanocytes to produce melanin. It performs lipid-mobilizing functions such as lipolysis and steroidogenesis. |
Protein Length | 267 Amino acids |
Molecular weight | 29424 |
References | 1 PubMed abstract 6274691 2 PubMed abstract 6299668 3 PubMed abstract 6314261 4 PubMed abstract 15489334 5 PubMed abstract 3606677 6 PubMed abstract 6254047 7 PubMed abstract 6945581 8 PubMed abstract 6267033 9 PubMed abstract 6272808 10 PubMed abstract 4352834 11 PubMed abstract 14463577 12 PubMed abstract 15340161 13 PubMed abstract 4334191 14 PubMed abstract 4338630 15 PubMed abstract 4347148 16 PubMed abstract 1264228 17 Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 18 PubMed abstract 195688 19 PubMed abstract 2424570 20 PubMed abstract 2839146 21 PubMed abstract 7828531 22 PubMed abstract 9620771 23 PubMed abstract 16046320 24 PubMed abstract 16807684 25 PubMed abstract 9768693 26 PubMed abstract 10193875 27 PubMed abstract 11244459 28 PubMed abstract 12165561 29 PubMed abstract 6274691 30 PubMed abstract 6299668 31 PubMed abstract 6314261 32 PubMed abstract 15489334 33 PubMed abstract 3606677 34 PubMed abstract 6254047 35 PubMed abstract 6945581 36 PubMed abstract 6267033 37 PubMed abstract 6272808 38 PubMed abstract 4352834 39 PubMed abstract 14463577 40 PubMed abstract 15340161 41 PubMed abstract 4334191 42 PubMed abstract 4338630 43 PubMed abstract 4347148 44 PubMed abstract 1264228 45 Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 46 PubMed abstract 195688 47 PubMed abstract 2424570 48 PubMed abstract 2839146 49 PubMed abstract 7828531 50 PubMed abstract 9620771 51 PubMed abstract 16046320 52 PubMed abstract 16807684 53 PubMed abstract 9768693 54 PubMed abstract 10193875 55 PubMed abstract 11244459 56 PubMed abstract 12165561 |
Domain Name | ACTH_domain NPP Op_neuropeptide |
Hormone Name | Lipotropin gamma (Gamma-LPH) |
Mature Hormone Sequence | ELTGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKD |
Position of mature hormone in Pre-Hormone protein | 56 Residues from position (179-234) |
Receptor | Q01726
Detail in HMRbase |
Gene ID | 5443 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11255 |
Swiss-prot Accession number | P01189 (Sequence in FASTA format) |
Description | Corticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Contains: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide;Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanotropin alpha(Alpha-MSH); Corticotropin-like intermediary peptide (CLIP);Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropinbeta (Beta-MSH); Beta-endorphin; Met-enkephalin]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | N/A |
Developmental Stage | N/A |
Similarity | Belongs to the POMC family. |
Tissue Specificity | ACTH and MSH are produced by the pituitary gland |
Post translational modification | Specific enzymatic cleavages at paired basic residues yield the different active peptides. O-glycosylated; reducing sugar is probably N- acetylgalactosamine. |
Function | MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes |
Protein Length | 267 Amino acids |
Molecular weight | 29424 |
References | 1 PubMed abstract 6274691 2 PubMed abstract 6299668 3 PubMed abstract 6314261 4 PubMed abstract 15489334 5 PubMed abstract 3606677 6 PubMed abstract 6254047 7 PubMed abstract 6945581 8 PubMed abstract 6267033 9 PubMed abstract 6272808 10 PubMed abstract 4352834 11 PubMed abstract 14463577 12 PubMed abstract 15340161 13 PubMed abstract 4334191 14 PubMed abstract 4338630 15 PubMed abstract 4347148 16 PubMed abstract 1264228 17 Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 18 PubMed abstract 195688 19 PubMed abstract 2424570 20 PubMed abstract 2839146 21 PubMed abstract 7828531 22 PubMed abstract 9620771 23 PubMed abstract 16046320 24 PubMed abstract 16807684 25 PubMed abstract 9768693 26 PubMed abstract 10193875 27 PubMed abstract 11244459 28 PubMed abstract 12165561 29 PubMed abstract 6274691 30 PubMed abstract 6299668 31 PubMed abstract 6314261 32 PubMed abstract 15489334 33 PubMed abstract 3606677 34 PubMed abstract 6254047 35 PubMed abstract 6945581 36 PubMed abstract 6267033 37 PubMed abstract 6272808 38 PubMed abstract 4352834 39 PubMed abstract 14463577 40 PubMed abstract 15340161 41 PubMed abstract 4334191 42 PubMed abstract 4338630 43 PubMed abstract 4347148 44 PubMed abstract 1264228 45 Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 46 PubMed abstract 195688 47 PubMed abstract 2424570 48 PubMed abstract 2839146 49 PubMed abstract 7828531 50 PubMed abstract 9620771 51 PubMed abstract 16046320 52 PubMed abstract 16807684 53 PubMed abstract 9768693 54 PubMed abstract 10193875 55 PubMed abstract 11244459 56 PubMed abstract 12165561 |
Domain Name | ACTH_domain NPP Op_neuropeptide |
Hormone Name | Melanotropin beta (Beta-MSH) |
Mature Hormone Sequence | DEGPYRMEHFRWGSPPKD |
Position of mature hormone in Pre-Hormone protein | 18 Residues from position (217-234) |
Receptor | Q01726
Detail in HMRbase |
Gene ID | 5443 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11256 |
Swiss-prot Accession number | P01189 (Sequence in FASTA format) |
Description | Corticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Contains: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide;Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanotropin alpha(Alpha-MSH); Corticotropin-like intermediary peptide (CLIP);Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropinbeta (Beta-MSH); Beta-endorphin; Met-enkephalin]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | N/A |
Developmental Stage | N/A |
Similarity | Belongs to the POMC family. |
Tissue Specificity | ACTH and MSH are produced by the pituitary gland |
Post translational modification | Specific enzymatic cleavages at paired basic residues yield the different active peptides. O-glycosylated; reducing sugar is probably N- acetylgalactosamine. |
Function | Beta-endorphin is an endogenous opiate |
Protein Length | 267 Amino acids |
Molecular weight | 29424 |
References | 1 PubMed abstract 6274691 2 PubMed abstract 6299668 3 PubMed abstract 6314261 4 PubMed abstract 15489334 5 PubMed abstract 3606677 6 PubMed abstract 6254047 7 PubMed abstract 6945581 8 PubMed abstract 6267033 9 PubMed abstract 6272808 10 PubMed abstract 4352834 11 PubMed abstract 14463577 12 PubMed abstract 15340161 13 PubMed abstract 4334191 14 PubMed abstract 4338630 15 PubMed abstract 4347148 16 PubMed abstract 1264228 17 Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 18 PubMed abstract 195688 19 PubMed abstract 2424570 20 PubMed abstract 2839146 21 PubMed abstract 7828531 22 PubMed abstract 9620771 23 PubMed abstract 16046320 24 PubMed abstract 16807684 25 PubMed abstract 9768693 26 PubMed abstract 10193875 27 PubMed abstract 11244459 28 PubMed abstract 12165561 29 PubMed abstract 6274691 30 PubMed abstract 6299668 31 PubMed abstract 6314261 32 PubMed abstract 15489334 33 PubMed abstract 3606677 34 PubMed abstract 6254047 35 PubMed abstract 6945581 36 PubMed abstract 6267033 37 PubMed abstract 6272808 38 PubMed abstract 4352834 39 PubMed abstract 14463577 40 PubMed abstract 15340161 41 PubMed abstract 4334191 42 PubMed abstract 4338630 43 PubMed abstract 4347148 44 PubMed abstract 1264228 45 Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 46 PubMed abstract 195688 47 PubMed abstract 2424570 48 PubMed abstract 2839146 49 PubMed abstract 7828531 50 PubMed abstract 9620771 51 PubMed abstract 16046320 52 PubMed abstract 16807684 53 PubMed abstract 9768693 54 PubMed abstract 10193875 55 PubMed abstract 11244459 56 PubMed abstract 12165561 |
Domain Name | ACTH_domain NPP Op_neuropeptide |
Hormone Name | Beta-endorphin |
Mature Hormone Sequence | YGGFMTSEKSQTPLVTLFKNAIIKNAYKKGE |
Position of mature hormone in Pre-Hormone protein | 31 Residues from position (237-267) |
Receptor | Q01726
Detail in HMRbase |
Gene ID | 5443 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11257 |
Swiss-prot Accession number | P01189 (Sequence in FASTA format) |
Description | Corticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Contains: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide;Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanotropin alpha(Alpha-MSH); Corticotropin-like intermediary peptide (CLIP);Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropinbeta (Beta-MSH); Beta-endorphin; Met-enkephalin]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | N/A |
Developmental Stage | N/A |
Similarity | Belongs to the POMC family. |
Tissue Specificity | ACTH and MSH are produced by the pituitary gland |
Post translational modification | Specific enzymatic cleavages at paired basic residues yield the different active peptides. O-glycosylated; reducing sugar is probably N- acetylgalactosamine. |
Function | Met-enkephalin is an endogenous opiate |
Protein Length | 267 Amino acids |
Molecular weight | 29424 |
References | 1 PubMed abstract 6274691 2 PubMed abstract 6299668 3 PubMed abstract 6314261 4 PubMed abstract 15489334 5 PubMed abstract 3606677 6 PubMed abstract 6254047 7 PubMed abstract 6945581 8 PubMed abstract 6267033 9 PubMed abstract 6272808 10 PubMed abstract 4352834 11 PubMed abstract 14463577 12 PubMed abstract 15340161 13 PubMed abstract 4334191 14 PubMed abstract 4338630 15 PubMed abstract 4347148 16 PubMed abstract 1264228 17 Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 18 PubMed abstract 195688 19 PubMed abstract 2424570 20 PubMed abstract 2839146 21 PubMed abstract 7828531 22 PubMed abstract 9620771 23 PubMed abstract 16046320 24 PubMed abstract 16807684 25 PubMed abstract 9768693 26 PubMed abstract 10193875 27 PubMed abstract 11244459 28 PubMed abstract 12165561 29 PubMed abstract 6274691 30 PubMed abstract 6299668 31 PubMed abstract 6314261 32 PubMed abstract 15489334 33 PubMed abstract 3606677 34 PubMed abstract 6254047 35 PubMed abstract 6945581 36 PubMed abstract 6267033 37 PubMed abstract 6272808 38 PubMed abstract 4352834 39 PubMed abstract 14463577 40 PubMed abstract 15340161 41 PubMed abstract 4334191 42 PubMed abstract 4338630 43 PubMed abstract 4347148 44 PubMed abstract 1264228 45 Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959). 46 PubMed abstract 195688 47 PubMed abstract 2424570 48 PubMed abstract 2839146 49 PubMed abstract 7828531 50 PubMed abstract 9620771 51 PubMed abstract 16046320 52 PubMed abstract 16807684 53 PubMed abstract 9768693 54 PubMed abstract 10193875 55 PubMed abstract 11244459 56 PubMed abstract 12165561 |
Domain Name | ACTH_domain NPP Op_neuropeptide |
Hormone Name | Met-enkephalin |
Mature Hormone Sequence | YGGFM |
Position of mature hormone in Pre-Hormone protein | 5 Residues from position (237-241) |
Receptor | Q01726
Detail in HMRbase |
Gene ID | 5443 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11299 |
Swiss-prot Accession number | P01215 (Sequence in FASTA format) |
Description | Glycoprotein hormones alpha chain precursor (Anterior pituitaryglycoprotein hormones common subunit alpha) (Follitropin alpha chain)(Follicle-stimulating hormone alpha chain) (FSH-alpha) (Lutropin alphachain) (Luteinizing hormone alpha chain) (LSH-alpha) (Thyrotropinalpha chain) (Thyroid-stimulating hormone alpha chain) (TSH-alpha)(Choriogonadotropin alpha chain) (Chorionic gonadotrophin alphasubunit) (CG-alpha). |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the glycoprotein hormones subunit alpha family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | N/A |
Protein Length | 116 Amino acids |
Molecular weight | 13075 |
References | 1 PubMed abstract 481597 2 PubMed abstract 8196184 3 PubMed abstract 15489334 4 PubMed abstract 6286817 5 PubMed abstract 7462224 6 PubMed abstract 890569 7 PubMed abstract 5065401 8 Keutmann H.T., Williams R.M., Bishop W.H., Ryan R.J.; "Structure of human luteninizing hormone."; Fed. Proc. 37:1828-1828(1978). 9 PubMed abstract 1158880 10 PubMed abstract 4835135 11 PubMed abstract 1150658 12 PubMed abstract 4745444 13 PubMed abstract 6774759 14 PubMed abstract 7410374 15 PubMed abstract 1991473 16 PubMed abstract 8202136 17 PubMed abstract 8898911 18 PubMed abstract 15662415 19 PubMed abstract 481597 20 PubMed abstract 8196184 21 PubMed abstract 15489334 22 PubMed abstract 6286817 23 PubMed abstract 7462224 24 PubMed abstract 890569 25 PubMed abstract 5065401 26 Keutmann H.T., Williams R.M., Bishop W.H., Ryan R.J.; "Structure of human luteninizing hormone."; Fed. Proc. 37:1828-1828(1978). 27 PubMed abstract 1158880 28 PubMed abstract 4835135 29 PubMed abstract 1150658 30 PubMed abstract 4745444 31 PubMed abstract 6774759 32 PubMed abstract 7410374 33 PubMed abstract 1991473 34 PubMed abstract 8202136 35 PubMed abstract 8898911 36 PubMed abstract 15662415 |
Domain Name | Hormone_6 |
Hormone Name | Glycoprotein hormones alpha chain |
Mature Hormone Sequence | APDVQDCPECTLQENPFFSQPGAPILQCMGCCFSRAYPTPLRSKKTMLVQKNVTSESTCCVAKSYNRVTVMGGFKVENHTACHCSTCYYHKS |
Position of mature hormone in Pre-Hormone protein | 92 Residues from position (25-116) |
Receptor | P23945 Detail in HMRbase P22888 Detail in HMRbase P16473 Detail in HMRbase |
Gene ID | 1081 |
PDB ID | 1DZ7 1E9J 1FL7 1HCN 1HD4 1HRP 1QFW 1XUL 1XWD |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11305 |
Swiss-prot Accession number | P01222 (Sequence in FASTA format) |
Description | Thyrotropin subunit beta precursor (Thyroid-stimulating hormonesubunit beta) (TSH-beta) (TSH-B) (Thyrotropin beta chain) (Thyrotropinalfa). |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted protein |
Developmental Stage | N/A |
Similarity | Belongs to the glycoprotein hormones subunit beta family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Indispensable for the control of thyroid structure and metabolism |
Protein Length | 138 Amino acids |
Molecular weight | 15609 |
References | 1 PubMed abstract 3839756 2 PubMed abstract 2457586 3 PubMed abstract 3234176 4 PubMed abstract 3243440 5 PubMed abstract 8196184 6 PubMed abstract 15489334 7 PubMed abstract 890569 |
Domain Name | Cys_knot |
Hormone Name | Thyroid-stimulating hormone subunit beta (TSH-B) (Thyrotropin beta chain) |
Mature Hormone Sequence | FCIPTEYTMHIERRECAYCLTINTTICAGYCMTRDINGKLFLPKYALSQDVCTYRDFIYRTVEIPGCPLHVAPYFSYPVALSCKCGKCNTDYSDCIHEAIKTNYCTKPQKSY |
Position of mature hormone in Pre-Hormone protein | 112 Residues from position (21-132) |
Receptor | P16473
Detail in HMRbase |
Gene ID | N/A |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11308 |
Swiss-prot Accession number | P01225 (Sequence in FASTA format) |
Description | Follitropin subunit beta precursor (Follicle-stimulating hormone betasubunit) (FSH-beta) (FSH-B) (Follitropin beta chain). |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the glycoprotein hormones subunit beta family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Stimulates development of follicle and spermatogenesis in the reproductive organs |
Protein Length | 129 Amino acids |
Molecular weight | 14700 |
References | 1 PubMed abstract 2885163 2 PubMed abstract 2494176 3 PubMed abstract 3139991 4 PubMed abstract 16554811 5 PubMed abstract 15489334 6 PubMed abstract 3151250 7 PubMed abstract 1249074 8 PubMed abstract 4835136 9 PubMed abstract 6774759 10 PubMed abstract 11501762 11 PubMed abstract 11222739 12 PubMed abstract 15662415 13 PubMed abstract 10391209 14 Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N.,Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L.,Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q.,Lander E.S.; Nat. Genet. 23:373-373(1999). 15 PubMed abstract 2885163 16 PubMed abstract 2494176 17 PubMed abstract 3139991 18 PubMed abstract 16554811 19 PubMed abstract 15489334 20 PubMed abstract 3151250 21 PubMed abstract 1249074 22 PubMed abstract 4835136 23 PubMed abstract 6774759 24 PubMed abstract 11501762 25 PubMed abstract 11222739 26 PubMed abstract 15662415 27 PubMed abstract 8220432 28 Layman L.C., Lee E.-J., Peak D.B., Namnoum A.B., Vu K.V.,van Lingen B.L., Gray M.R., McDonough P.G., Reindollar R.H.,Jameson J.L.; "Delayed puberty and hypogonadism caused by mutations in the follicle-stimulating hormone beta-subunit gene."; N. Engl. J. Med. 337:607-611(1997). 29 PubMed abstract 9280841 30 PubMed abstract 10391209 31 Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N.,Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L.,Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q.,Lander E.S.; Nat. Genet. 23:373-373(1999). |
Domain Name | Cys_knot |
Hormone Name | Follicle-stimulating hormone beta subunit |
Mature Hormone Sequence | NSCELTNITIAIEKEECRFCISINTTWCAGYCYTRDLVYKDPARPKIQKTCTFKELVYETVRVPGCAHHADSLYTYPVATQCHCGKCDSDSTDCTVRGLGPSYCSFGEMKE |
Position of mature hormone in Pre-Hormone protein | 111 Residues from position (19-129) |
Receptor | P23945
Detail in HMRbase |
Gene ID | 2488 |
PDB ID | 1FL7 1XWD |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11311 |
Swiss-prot Accession number | P01229 (Sequence in FASTA format) |
Description | Lutropin subunit beta precursor (Luteinizing hormone subunit beta)(LSH-beta) (LSH-B) (LH-B) (Lutropin beta chain). |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted protein |
Developmental Stage | N/A |
Similarity | Belongs to the glycoprotein hormones subunit beta family. |
Tissue Specificity | Pituitary gland |
Post translational modification | N/A |
Function | Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids |
Protein Length | 141 Amino acids |
Molecular weight | 15345 |
References | 1 PubMed abstract 6690982 2 PubMed abstract 1191677 3 PubMed abstract 4685398 4 PubMed abstract 4719207 5 PubMed abstract 1991473 6 PubMed abstract 1495492 7 PubMed abstract 1727547 8 PubMed abstract 9457942 9 PubMed abstract 9886510 10 PubMed abstract 11870227 |
Domain Name | Cys_knot |
Hormone Name | Luteinizing hormone subunit beta (LSH-B) (LH-B)(Lutropin subunit beta) |
Mature Hormone Sequence | SREPLRPWCHPINAILAVEKEGCPVCITVNTTICAGYCPTMMRVLQAVLPPLPQVVCTYRDVRFESIRLPGCPRGVDPVVSFPVALSCRCGPCRRSTSDCGGPKDHPLTCDHPQLSGLLFL |
Position of mature hormone in Pre-Hormone protein | 121 Residues from position (21-141) |
Receptor | P22888
Detail in HMRbase |
Gene ID | 3972 |
PDB ID | 1M92 |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11314 |
Swiss-prot Accession number | P01236 (Sequence in FASTA format) |
Description | Prolactin precursor (PRL). |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the somatotropin/prolactin family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Prolactin acts primarily on the mammary gland by promoting lactation |
Protein Length | 227 Amino acids |
Molecular weight | 25876 |
References | 1 PubMed abstract 6260780 2 PubMed abstract 6325171 3 PubMed abstract 2050267 4 PubMed abstract 15489334 5 PubMed abstract 6146607 6 PubMed abstract 9266104 7 PubMed abstract 925136 8 PubMed abstract 1126929 |
Domain Name | Hormone_1 |
Hormone Name | Prolactin |
Mature Hormone Sequence | LPICPGGAARCQVTLRDLFDRAVVLSHYIHNLSSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWNEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSGLPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC |
Position of mature hormone in Pre-Hormone protein | 199 Residues from position (29-227) |
Receptor | P16471
Detail in HMRbase |
Gene ID | 5617 |
PDB ID | 1N9D 1RW5 2Q98 3D48 |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11319 |
Swiss-prot Accession number | P01241 (Sequence in FASTA format) |
Description | Somatotropin precursor (Growth hormone) (GH) (GH-N) (Pituitary growthhormone) (Growth hormone 1). |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted protein |
Developmental Stage | N/A |
Similarity | Belongs to the somatotropin/prolactin family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues |
Protein Length | 217 Amino acids |
Molecular weight | 24847 |
References | 1 PubMed abstract 386281 2 PubMed abstract 377496 3 PubMed abstract 6269091 4 PubMed abstract 7169009 5 PubMed abstract 2744760 6 Gu J., Huang Q.-H., Li N., Xu S.-H., Han Z.-G., Fu G., Chen Z.; "A novel gene expressed in human pituitary."; Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases. 7 PubMed abstract 10931946 8 PubMed abstract 15489334 9 PubMed abstract 3912261 10 PubMed abstract 5810834 11 PubMed abstract 5144027 12 PubMed abstract 4675454 13 PubMed abstract 5279046 14 PubMed abstract 5279528 15 Niall H.D.; "The chemistry of the human lactogenic hormones."; (In) Griffiths K. (eds.);Prolactin and carcinogenesis, Proc. fourth tenovus workshop prolactin,pp.13-20, Alpha Omega Alpha Press, Cardiff (1972). 16 PubMed abstract 7462247 17 PubMed abstract 7356479 18 PubMed abstract 7028740 19 PubMed abstract 14997482 20 PubMed abstract 10393484 21 PubMed abstract 16807684 22 PubMed abstract 3447173 23 PubMed abstract 1549776 24 PubMed abstract 7984244 25 Chantalat L., Chirgadze N.Y., Jones N., Korber F., Navaza J.,Pavlovsk A.G., Wlodawer A.; "The crystal-structure of wild-type growth-hormone at 2.5-Aresolution."; Protein Pept. Lett. 2:333-340(1995). 26 PubMed abstract 8943276 27 PubMed abstract 8552145 28 Takahashi Y., Kaji H., Okimura Y., Goji K., Abe H., Chihara K.; N. Engl. J. Med. 334:1207-1207(1996). 29 PubMed abstract 9276733 30 PubMed abstract 10391209 31 Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N.,Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L.,Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q.,Lander E.S.; Nat. Genet. 23:373-373(1999). 32 PubMed abstract 11502836 33 PubMed abstract 12655557 |
Domain Name | Hormone_1 |
Hormone Name | Growth hormone (Somatotropin) (GH) |
Mature Hormone Sequence | FPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF |
Position of mature hormone in Pre-Hormone protein | 191 Residues from position (27-217) |
Receptor | P10912
Detail in HMRbase |
Gene ID | 2688 |
PDB ID | 1A22 1AXI 1BP3 1HGU 1HUW 1HWG 1HWH 1KF9 3HHR |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11323 |
Swiss-prot Accession number | P01258 (Sequence in FASTA format) |
Description | Calcitonin precursor [Contains: Calcitonin; Katacalcin (Calcitonincarboxyl-terminal peptide) (CCP) (PDN-21)]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the calcitonin family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones |
Protein Length | 141 Amino acids |
Molecular weight | 15467 |
References | 1 PubMed abstract 6546550 2 PubMed abstract 3872459 3 PubMed abstract 3485540 4 PubMed abstract 3034287 5 PubMed abstract 2571128 6 PubMed abstract 1761559 7 Livingston R.J., Rieder M.J., Shaffer T., Bertucci C., Baier C.N.,Rajkumar N., Willa H.T., Daniels M., Downing T.K., Stanaway I.B.,Nguyen C.P., Gildersleeve H., Cassidy C.M., Johnson E.J.,Swanson J.E., McFarland I., Yool B., Park C., Nickerson D.A.; "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Departmentof Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)."; Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases. 8 PubMed abstract 15489334 9 PubMed abstract 2408883 10 PubMed abstract 6148938 11 PubMed abstract 5760861 12 PubMed abstract 2001366 13 PubMed abstract 6132180 14 PubMed abstract 14759258 |
Domain Name | Calc_CGRP_IAPP |
Hormone Name | Calcitonin |
Mature Hormone Sequence | CGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAP |
Position of mature hormone in Pre-Hormone protein | 32 Residues from position (85-116) |
Receptor | P30988
Detail in HMRbase |
Gene ID | 796 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11324 |
Swiss-prot Accession number | P01258 (Sequence in FASTA format) |
Description | Calcitonin precursor [Contains: Calcitonin; Katacalcin (Calcitonincarboxyl-terminal peptide) (CCP) (PDN-21)]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the calcitonin family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Katacalcin is a potent plasma calcium-lowering peptide |
Protein Length | 141 Amino acids |
Molecular weight | 15467 |
References | 1 PubMed abstract 6546550 2 PubMed abstract 3872459 3 PubMed abstract 3485540 4 PubMed abstract 3034287 5 PubMed abstract 2571128 6 PubMed abstract 1761559 7 Livingston R.J., Rieder M.J., Shaffer T., Bertucci C., Baier C.N.,Rajkumar N., Willa H.T., Daniels M., Downing T.K., Stanaway I.B.,Nguyen C.P., Gildersleeve H., Cassidy C.M., Johnson E.J.,Swanson J.E., McFarland I., Yool B., Park C., Nickerson D.A.; "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Departmentof Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)."; Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases. 8 PubMed abstract 15489334 9 PubMed abstract 2408883 10 PubMed abstract 6148938 11 PubMed abstract 5760861 12 PubMed abstract 2001366 13 PubMed abstract 6132180 14 PubMed abstract 14759258 |
Domain Name | Calc_CGRP_IAPP |
Hormone Name | Katacalcin |
Mature Hormone Sequence | DMSSDLERDHRPHVSMPQNAN |
Position of mature hormone in Pre-Hormone protein | 21 Residues from position (121-141) |
Receptor | P30988
Detail in HMRbase |
Gene ID | 796 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11328 |
Swiss-prot Accession number | P01270 (Sequence in FASTA format) |
Description | Parathyroid hormone precursor (Parathyrin) (PTH) (Parathormone). |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted protein |
Developmental Stage | N/A |
Similarity | Belongs to the parathyroid hormone family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion |
Protein Length | 115 Amino acids |
Molecular weight | 12861 |
References | 1 PubMed abstract 6950381 2 PubMed abstract 6220408 3 PubMed abstract 15489334 4 PubMed abstract 4833516 5 PubMed abstract 15340161 6 PubMed abstract 4521809 7 PubMed abstract 728431 8 Keutmann H.T., Niall H.D., Jacobs J.W., Barling P.M., Hendy G.N.,O'Riordan J.L.H., Potts J.T. Jr.; (In) Talmadge R.V., Owen M., Parsons J.A. (eds.);Calcium-regulating hormones, pp.9-14, Excerpta Medica Foundation,Amsterdam (1975). 9 PubMed abstract 1125201 10 PubMed abstract 4474131 11 PubMed abstract 4721748 12 PubMed abstract 2069952 13 PubMed abstract 8344299 14 PubMed abstract 7797503 15 PubMed abstract 10623601 16 PubMed abstract 2212001 17 PubMed abstract 10523031 |
Domain Name | Parathyroid |
Hormone Name | Parathyroid hormone (Parathyrin) (PTH) |
Mature Hormone Sequence | SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNFVALGAPLAPRDAGSQRPRKKEDNVLVESHEKSLGEADKADVNVLTKAKSQ |
Position of mature hormone in Pre-Hormone protein | 84 Residues from position (32-115) |
Receptor | Q03431
Detail in HMRbase |
Gene ID | 5741 |
PDB ID | 1BWX 1ET1 1ET2 1FVY 1HPH 1HPY 1HTH 1ZWA 1ZWB 1ZWD 1ZWE 1ZWF 1ZWG |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11329 |
Swiss-prot Accession number | P01275 (Sequence in FASTA format) |
Description | Glucagon precursor [Contains: Glicentin; Glicentin-related polypeptide(GRPP); Oxyntomodulin (OXY) (OXM); Glucagon; Glucagon-like peptide 1(GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-likepeptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the glucagon family. |
Tissue Specificity | Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain |
Post translational modification | Proglucagon is posttranslationally processed in a tissue- specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by posttranslational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas. |
Function | Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life |
Protein Length | 180 Amino acids |
Molecular weight | 20909 |
References | 1 PubMed abstract 2901414 2 PubMed abstract 3725587 3 PubMed abstract 6877358 4 Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 5 PubMed abstract 15815621 6 PubMed abstract 15489334 7 PubMed abstract 11946536 8 PubMed abstract 2753890 9 PubMed abstract 8482423 10 PubMed abstract 14557443 11 PubMed abstract 14632334 12 PubMed abstract 9287128 13 PubMed abstract 12651102 14 PubMed abstract 14719035 15 PubMed abstract 12554744 16 PubMed abstract 12626323 17 PubMed abstract 10322410 18 PubMed abstract 10605628 19 PubMed abstract 9667960 20 PubMed abstract 11943215 21 PubMed abstract 12627948 |
Domain Name | Hormone_2 |
Hormone Name | Glicentin |
Mature Hormone Sequence | RSLQDTEEKSRSFSASQADPLSDPDQMNEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIA |
Position of mature hormone in Pre-Hormone protein | 69 Residues from position (21-89) |
Receptor | P47871
Detail in HMRbase |
Gene ID | 2641 |
PDB ID | 1BH0 1D0R 1NAU |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11330 |
Swiss-prot Accession number | P01275 (Sequence in FASTA format) |
Description | Glucagon precursor [Contains: Glicentin; Glicentin-related polypeptide(GRPP); Oxyntomodulin (OXY) (OXM); Glucagon; Glucagon-like peptide 1(GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-likepeptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the glucagon family. |
Tissue Specificity | Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain |
Post translational modification | Proglucagon is posttranslationally processed in a tissue- specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by posttranslational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas. |
Function | Oxyntomodulin significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness |
Protein Length | 180 Amino acids |
Molecular weight | 20909 |
References | 1 PubMed abstract 2901414 2 PubMed abstract 3725587 3 PubMed abstract 6877358 4 Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 5 PubMed abstract 15815621 6 PubMed abstract 15489334 7 PubMed abstract 11946536 8 PubMed abstract 2753890 9 PubMed abstract 8482423 10 PubMed abstract 14557443 11 PubMed abstract 14632334 12 PubMed abstract 9287128 13 PubMed abstract 12651102 14 PubMed abstract 14719035 15 PubMed abstract 12554744 16 PubMed abstract 12626323 17 PubMed abstract 10322410 18 PubMed abstract 10605628 19 PubMed abstract 9667960 20 PubMed abstract 11943215 21 PubMed abstract 12627948 |
Domain Name | Hormone_2 |
Hormone Name | Oxyntomodulin |
Mature Hormone Sequence | HSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIA |
Position of mature hormone in Pre-Hormone protein | 37 Residues from position (53-89) |
Receptor | P47871
Detail in HMRbase |
Gene ID | 2641 |
PDB ID | 1BH0 1D0R 1NAU |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11331 |
Swiss-prot Accession number | P01275 (Sequence in FASTA format) |
Description | Glucagon precursor [Contains: Glicentin; Glicentin-related polypeptide(GRPP); Oxyntomodulin (OXY) (OXM); Glucagon; Glucagon-like peptide 1(GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-likepeptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the glucagon family. |
Tissue Specificity | Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain |
Post translational modification | Proglucagon is posttranslationally processed in a tissue- specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by posttranslational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas. |
Function | Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes |
Protein Length | 180 Amino acids |
Molecular weight | 20909 |
References | 1 PubMed abstract 2901414 2 PubMed abstract 3725587 3 PubMed abstract 6877358 4 Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 5 PubMed abstract 15815621 6 PubMed abstract 15489334 7 PubMed abstract 11946536 8 PubMed abstract 2753890 9 PubMed abstract 8482423 10 PubMed abstract 14557443 11 PubMed abstract 14632334 12 PubMed abstract 9287128 13 PubMed abstract 12651102 14 PubMed abstract 14719035 15 PubMed abstract 12554744 16 PubMed abstract 12626323 17 PubMed abstract 10322410 18 PubMed abstract 10605628 19 PubMed abstract 9667960 20 PubMed abstract 11943215 21 PubMed abstract 12627948 |
Domain Name | Hormone_2 |
Hormone Name | Glucagon |
Mature Hormone Sequence | HSQGTFTSDYSKYLDSRRAQDFVQWLMNT |
Position of mature hormone in Pre-Hormone protein | 29 Residues from position (53-81) |
Receptor | P47871
Detail in HMRbase |
Gene ID | 2641 |
PDB ID | 1BH0 1D0R 1NAU |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11332 |
Swiss-prot Accession number | P01275 (Sequence in FASTA format) |
Description | Glucagon precursor [Contains: Glicentin; Glicentin-related polypeptide(GRPP); Oxyntomodulin (OXY) (OXM); Glucagon; Glucagon-like peptide 1(GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-likepeptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the glucagon family. |
Tissue Specificity | Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain |
Post translational modification | Proglucagon is posttranslationally processed in a tissue- specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by posttranslational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas. |
Function | GLP-1 is a potent stimulator of glucose-dependent insulin release. Play important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Have growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferaton. Inhibits beta cell apoptosis |
Protein Length | 180 Amino acids |
Molecular weight | 20909 |
References | 1 PubMed abstract 2901414 2 PubMed abstract 3725587 3 PubMed abstract 6877358 4 Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 5 PubMed abstract 15815621 6 PubMed abstract 15489334 7 PubMed abstract 11946536 8 PubMed abstract 2753890 9 PubMed abstract 8482423 10 PubMed abstract 14557443 11 PubMed abstract 14632334 12 PubMed abstract 9287128 13 PubMed abstract 12651102 14 PubMed abstract 14719035 15 PubMed abstract 12554744 16 PubMed abstract 12626323 17 PubMed abstract 10322410 18 PubMed abstract 10605628 19 PubMed abstract 9667960 20 PubMed abstract 11943215 21 PubMed abstract 12627948 |
Domain Name | Hormone_2 |
Hormone Name | Glucagon-like peptide 1 |
Mature Hormone Sequence | HDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG |
Position of mature hormone in Pre-Hormone protein | 37 Residues from position (92-128) |
Receptor | P47871
Detail in HMRbase |
Gene ID | 2641 |
PDB ID | 1BH0 1D0R 1NAU |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11333 |
Swiss-prot Accession number | P01275 (Sequence in FASTA format) |
Description | Glucagon precursor [Contains: Glicentin; Glicentin-related polypeptide(GRPP); Oxyntomodulin (OXY) (OXM); Glucagon; Glucagon-like peptide 1(GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-likepeptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the glucagon family. |
Tissue Specificity | Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain |
Post translational modification | Proglucagon is posttranslationally processed in a tissue- specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by posttranslational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas. |
Function | GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability |
Protein Length | 180 Amino acids |
Molecular weight | 20909 |
References | 1 PubMed abstract 2901414 2 PubMed abstract 3725587 3 PubMed abstract 6877358 4 Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 5 PubMed abstract 15815621 6 PubMed abstract 15489334 7 PubMed abstract 11946536 8 PubMed abstract 2753890 9 PubMed abstract 8482423 10 PubMed abstract 14557443 11 PubMed abstract 14632334 12 PubMed abstract 9287128 13 PubMed abstract 12651102 14 PubMed abstract 14719035 15 PubMed abstract 12554744 16 PubMed abstract 12626323 17 PubMed abstract 10322410 18 PubMed abstract 10605628 19 PubMed abstract 9667960 20 PubMed abstract 11943215 21 PubMed abstract 12627948 |
Domain Name | Hormone_2 |
Hormone Name | Glucagon-like peptide 2 |
Mature Hormone Sequence | HADGSFSDEMNTILDNLAARDFINWLIQTKITD |
Position of mature hormone in Pre-Hormone protein | 33 Residues from position (146-178) |
Receptor | P47871
Detail in HMRbase |
Gene ID | 2641 |
PDB ID | 1BH0 1D0R 1NAU |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11334 |
Swiss-prot Accession number | P01286 (Sequence in FASTA format) |
Description | Somatoliberin precursor (Growth hormone-releasing factor) (GRF)(Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin)(Sermorelin). |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted protein |
Developmental Stage | N/A |
Similarity | Belongs to the glucagon family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone |
Protein Length | 108 Amino acids |
Molecular weight | 12447 |
References | 1 PubMed abstract 6192430 2 PubMed abstract 3918305 3 PubMed abstract 11780052 4 PubMed abstract 15489334 5 PubMed abstract 6415488 6 PubMed abstract 6812220 7 PubMed abstract 2854259 8 PubMed abstract 3029387 |
Domain Name | Hormone_2 |
Hormone Name | Growth hormone-releasing factor (GRF) (Growth hormone-releasing hormone) (GHRH) |
Mature Hormone Sequence | YADAIFTNSYRKVLGQLSARKLLQDIMSRQQGESNQERGARARL |
Position of mature hormone in Pre-Hormone protein | 44 Residues from position (32-75) |
Receptor | Q02643
Detail in HMRbase |
Gene ID | 2691 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11336 |
Swiss-prot Accession number | P01308 (Sequence in FASTA format) |
Description | Insulin precursor [Contains: Insulin B chain; Insulin A chain]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the insulin family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver |
Protein Length | 110 Amino acids |
Molecular weight | 11981 |
References | 1 PubMed abstract 6243748 2 PubMed abstract 6248962 3 PubMed abstract 503234 4 PubMed abstract 6927840 5 PubMed abstract 8358440 6 Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases. 7 PubMed abstract 15489334 8 Fajardy I.I., Weill J.J., Stuckens C.C., Danze P.M.P.; "Description of a novel RFLP diallelic polymorphism (-127 BsgI C/G)within the 5' region of insulin gene."; Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases. 9 PubMed abstract 14426955 10 PubMed abstract 5101771 11 PubMed abstract 5560404 12 PubMed abstract 4443293 13 PubMed abstract 4803504 14 PubMed abstract 4698555 15 PubMed abstract 4698553 16 PubMed abstract 6312455 17 PubMed abstract 6424111 18 PubMed abstract 3470784 19 PubMed abstract 3537011 20 PubMed abstract 2196279 21 PubMed abstract 4019786 22 PubMed abstract 1601997 23 PubMed abstract 2271664 24 PubMed abstract 2036420 25 PubMed abstract 1646635 26 PubMed abstract 1433291 27 PubMed abstract 8421693 28 PubMed abstract 9235985 |
Domain Name | Insulin |
Hormone Name | Insulin B chain |
Mature Hormone Sequence | FVNQHLCGSHLVEALYLVCGERGFFYTPKT |
Position of mature hormone in Pre-Hormone protein | 30 Residues from position (25-54) |
Receptor | P06213
Detail in HMRbase |
Gene ID | 3630 |
PDB ID | 1A7F 1AI0 1AIY 1B9E 1BEN 1EFE 1EV3 1EV6 1EVR 1FU2 1FUB 1G7A 1G7B 1GUJ 1HIQ 1HIS 1HIT 1HLS 1HTV 1HUI 1IOG 1IOH 1J73 1JCA 1JCO 1K3M 1KMF 1LKQ 1LPH 1MHI 1MHJ 1MSO 1OS3 1OS4 1QIY 1QIZ 1QJ0 1RWE 1SF1 1SJT 1SJU 1T0C 1T1K 1T1P 1T1Q 1TRZ 1TYL 1TYM 1UZ9 1VKT 1W8P |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11337 |
Swiss-prot Accession number | P01308 (Sequence in FASTA format) |
Description | Insulin precursor [Contains: Insulin B chain; Insulin A chain]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the insulin family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver |
Protein Length | 110 Amino acids |
Molecular weight | 11981 |
References | 1 PubMed abstract 6243748 2 PubMed abstract 6248962 3 PubMed abstract 503234 4 PubMed abstract 6927840 5 PubMed abstract 8358440 6 Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases. 7 PubMed abstract 15489334 8 Fajardy I.I., Weill J.J., Stuckens C.C., Danze P.M.P.; "Description of a novel RFLP diallelic polymorphism (-127 BsgI C/G)within the 5' region of insulin gene."; Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases. 9 PubMed abstract 14426955 10 PubMed abstract 5101771 11 PubMed abstract 5560404 12 PubMed abstract 4443293 13 PubMed abstract 4803504 14 PubMed abstract 4698555 15 PubMed abstract 4698553 16 PubMed abstract 6312455 17 PubMed abstract 6424111 18 PubMed abstract 3470784 19 PubMed abstract 3537011 20 PubMed abstract 2196279 21 PubMed abstract 4019786 22 PubMed abstract 1601997 23 PubMed abstract 2271664 24 PubMed abstract 2036420 25 PubMed abstract 1646635 26 PubMed abstract 1433291 27 PubMed abstract 8421693 28 PubMed abstract 9235985 |
Domain Name | Insulin |
Hormone Name | Insulin A chain |
Mature Hormone Sequence | GIVEQCCTSICSLYQLENYCN |
Position of mature hormone in Pre-Hormone protein | 21 Residues from position (90-110) |
Receptor | P06213
Detail in HMRbase |
Gene ID | 3630 |
PDB ID | 1A7F 1AI0 1AIY 1B9E 1BEN 1EFE 1EV3 1EV6 1EVR 1FU2 1FUB 1G7A 1G7B 1GUJ 1HIQ 1HIS 1HIT 1HLS 1HTV 1HUI 1IOG 1IOH 1J73 1JCA 1JCO 1K3M 1KMF 1LKQ 1LPH 1MHI 1MHJ 1MSO 1OS3 1OS4 1QIY 1QIZ 1QJ0 1RWE 1SF1 1SJT 1SJU 1T0C 1T1K 1T1P 1T1Q 1TRZ 1TYL 1TYM 1UZ9 1VKT 1W8P |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11344 |
Swiss-prot Accession number | P01350 (Sequence in FASTA format) |
Description | Gastrin precursor [Contains: Gastrin-71 (Component I); Gastrin-52(G52); Big gastrin (Gastrin-34) (G34) (Component II); Gastrin(Gastrin-17) (G17) (Component III); Gastrin-14 (G14); Gastrin-6 (G6)]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the gastrin/cholecystokinin family. |
Tissue Specificity | N/A |
Post translational modification | Two different processing pathways probably exist in antral G- cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71. Sulfation of Tyr-87 blocks peptide degradation and enhances activity. |
Function | Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine |
Protein Length | 101 Amino acids |
Molecular weight | 11394 |
References | 1 PubMed abstract 3034736 2 PubMed abstract 6087340 3 PubMed abstract 6324077 4 PubMed abstract 6574456 5 PubMed abstract 6322186 6 PubMed abstract 6689486 7 PubMed abstract 15489334 8 PubMed abstract 8055952 9 PubMed abstract 5921183 10 PubMed abstract 2730647 11 PubMed abstract 5822140 12 PubMed abstract 7530658 13 PubMed abstract 11052986 |
Domain Name | Gastrin |
Hormone Name | Gastrin-71 |
Mature Hormone Sequence | SWKPRSQQPDAPLGTGANRDLELPWLEQQGPASHHRRQLGPQGPPHLVADPSKKQGPWLEEEEEAYGWMDF |
Position of mature hormone in Pre-Hormone protein | 71 Residues from position (22-92) |
Receptor | P32239
Detail in HMRbase |
Gene ID | 2520 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11345 |
Swiss-prot Accession number | P01350 (Sequence in FASTA format) |
Description | Gastrin precursor [Contains: Gastrin-71 (Component I); Gastrin-52(G52); Big gastrin (Gastrin-34) (G34) (Component II); Gastrin(Gastrin-17) (G17) (Component III); Gastrin-14 (G14); Gastrin-6 (G6)]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the gastrin/cholecystokinin family. |
Tissue Specificity | N/A |
Post translational modification | Two different processing pathways probably exist in antral G- cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71. Sulfation of Tyr-87 blocks peptide degradation and enhances activity. |
Function | Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine |
Protein Length | 101 Amino acids |
Molecular weight | 11394 |
References | 1 PubMed abstract 3034736 2 PubMed abstract 6087340 3 PubMed abstract 6324077 4 PubMed abstract 6574456 5 PubMed abstract 6322186 6 PubMed abstract 6689486 7 PubMed abstract 15489334 8 PubMed abstract 8055952 9 PubMed abstract 5921183 10 PubMed abstract 2730647 11 PubMed abstract 5822140 12 PubMed abstract 7530658 13 PubMed abstract 11052986 |
Domain Name | Gastrin |
Hormone Name | Gastrin-52 |
Mature Hormone Sequence | DLELPWLEQQGPASHHRRQLGPQGPPHLVADPSKKQGPWLEEEEEAYGWMDF |
Position of mature hormone in Pre-Hormone protein | 52 Residues from position (41-92) |
Receptor | P32239
Detail in HMRbase |
Gene ID | 2520 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11346 |
Swiss-prot Accession number | P01350 (Sequence in FASTA format) |
Description | Gastrin precursor [Contains: Gastrin-71 (Component I); Gastrin-52(G52); Big gastrin (Gastrin-34) (G34) (Component II); Gastrin(Gastrin-17) (G17) (Component III); Gastrin-14 (G14); Gastrin-6 (G6)]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the gastrin/cholecystokinin family. |
Tissue Specificity | N/A |
Post translational modification | Two different processing pathways probably exist in antral G- cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71. Sulfation of Tyr-87 blocks peptide degradation and enhances activity. |
Function | Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine |
Protein Length | 101 Amino acids |
Molecular weight | 11394 |
References | 1 PubMed abstract 3034736 2 PubMed abstract 6087340 3 PubMed abstract 6324077 4 PubMed abstract 6574456 5 PubMed abstract 6322186 6 PubMed abstract 6689486 7 PubMed abstract 15489334 8 PubMed abstract 8055952 9 PubMed abstract 5921183 10 PubMed abstract 2730647 11 PubMed abstract 5822140 12 PubMed abstract 7530658 13 PubMed abstract 11052986 |
Domain Name | Gastrin |
Hormone Name | Big gastrin |
Mature Hormone Sequence | QLGPQGPPHLVADPSKKQGPWLEEEEEAYGWMDF |
Position of mature hormone in Pre-Hormone protein | 34 Residues from position (59-92) |
Receptor | P32239
Detail in HMRbase |
Gene ID | 2520 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11347 |
Swiss-prot Accession number | P01350 (Sequence in FASTA format) |
Description | Gastrin precursor [Contains: Gastrin-71 (Component I); Gastrin-52(G52); Big gastrin (Gastrin-34) (G34) (Component II); Gastrin(Gastrin-17) (G17) (Component III); Gastrin-14 (G14); Gastrin-6 (G6)]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the gastrin/cholecystokinin family. |
Tissue Specificity | N/A |
Post translational modification | Two different processing pathways probably exist in antral G- cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71. Sulfation of Tyr-87 blocks peptide degradation and enhances activity. |
Function | Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine |
Protein Length | 101 Amino acids |
Molecular weight | 11394 |
References | 1 PubMed abstract 3034736 2 PubMed abstract 6087340 3 PubMed abstract 6324077 4 PubMed abstract 6574456 5 PubMed abstract 6322186 6 PubMed abstract 6689486 7 PubMed abstract 15489334 8 PubMed abstract 8055952 9 PubMed abstract 5921183 10 PubMed abstract 2730647 11 PubMed abstract 5822140 12 PubMed abstract 7530658 13 PubMed abstract 11052986 |
Domain Name | Gastrin |
Hormone Name | Gastrin |
Mature Hormone Sequence | QGPWLEEEEEAYGWMDF |
Position of mature hormone in Pre-Hormone protein | 17 Residues from position (76-92) |
Receptor | P32239
Detail in HMRbase |
Gene ID | 2520 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11348 |
Swiss-prot Accession number | P01350 (Sequence in FASTA format) |
Description | Gastrin precursor [Contains: Gastrin-71 (Component I); Gastrin-52(G52); Big gastrin (Gastrin-34) (G34) (Component II); Gastrin(Gastrin-17) (G17) (Component III); Gastrin-14 (G14); Gastrin-6 (G6)]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the gastrin/cholecystokinin family. |
Tissue Specificity | N/A |
Post translational modification | Two different processing pathways probably exist in antral G- cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71. Sulfation of Tyr-87 blocks peptide degradation and enhances activity. |
Function | Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine |
Protein Length | 101 Amino acids |
Molecular weight | 11394 |
References | 1 PubMed abstract 3034736 2 PubMed abstract 6087340 3 PubMed abstract 6324077 4 PubMed abstract 6574456 5 PubMed abstract 6322186 6 PubMed abstract 6689486 7 PubMed abstract 15489334 8 PubMed abstract 8055952 9 PubMed abstract 5921183 10 PubMed abstract 2730647 11 PubMed abstract 5822140 12 PubMed abstract 7530658 13 PubMed abstract 11052986 |
Domain Name | Gastrin |
Hormone Name | Gastrin-14 |
Mature Hormone Sequence | WLEEEEEAYGWMDF |
Position of mature hormone in Pre-Hormone protein | 14 Residues from position (79-92) |
Receptor | P32239
Detail in HMRbase |
Gene ID | 2520 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11349 |
Swiss-prot Accession number | P01350 (Sequence in FASTA format) |
Description | Gastrin precursor [Contains: Gastrin-71 (Component I); Gastrin-52(G52); Big gastrin (Gastrin-34) (G34) (Component II); Gastrin(Gastrin-17) (G17) (Component III); Gastrin-14 (G14); Gastrin-6 (G6)]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the gastrin/cholecystokinin family. |
Tissue Specificity | N/A |
Post translational modification | Two different processing pathways probably exist in antral G- cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71. Sulfation of Tyr-87 blocks peptide degradation and enhances activity. |
Function | Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine |
Protein Length | 101 Amino acids |
Molecular weight | 11394 |
References | 1 PubMed abstract 3034736 2 PubMed abstract 6087340 3 PubMed abstract 6324077 4 PubMed abstract 6574456 5 PubMed abstract 6322186 6 PubMed abstract 6689486 7 PubMed abstract 15489334 8 PubMed abstract 8055952 9 PubMed abstract 5921183 10 PubMed abstract 2730647 11 PubMed abstract 5822140 12 PubMed abstract 7530658 13 PubMed abstract 11052986 |
Domain Name | Gastrin |
Hormone Name | Gastrin-6 |
Mature Hormone Sequence | YGWMDF |
Position of mature hormone in Pre-Hormone protein | 6 Residues from position (87-92) |
Receptor | P32239
Detail in HMRbase |
Gene ID | 2520 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11360 |
Swiss-prot Accession number | P03971 (Sequence in FASTA format) |
Description | Muellerian-inhibiting factor precursor (MIS) (Anti-Muellerian hormone)(AMH) (Muellerian-inhibiting substance). |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted protein |
Developmental Stage | N/A |
Similarity | Belongs to the TGF-beta family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin |
Protein Length | 560 Amino acids |
Molecular weight | 59193 |
References | 1 PubMed abstract 3754790 2 PubMed abstract 15057824 3 PubMed abstract 1483695 4 PubMed abstract 8162013 5 PubMed abstract 8872466 |
Domain Name | N/A |
Hormone Name | Muellerian-inhibiting factor |
Mature Hormone Sequence | RAEEPAVGTSGLIFREDLDWPPGIPQEPLCLVALGGDSNGSSSPLRVVGALSAYEQAFLGAVQRARWGPRDLATFGVCNTGDRQAALPSLRRLGAWLRDPGGQRLVVLHLEEVTWEPTPSLRFQEPPPGGAGPPELALLVLYPGPGPEVTVTRAGLPGAQSLCPSRDTRYLVLAVDRPAGAWRGSGLALTLQPRGEDSRLSTARLQALLFGDDHRCFTRMTPALLLLPRSEPAPLPAHGQLDTVPFPPPRPSAELEESPPSADPFLETLTRLVRALRVPPARASAPRLALDPDALAGFPQGLVNLSDPAALERLLDGEEPLLLLLRPTAATTGDPAPLHDPTSAPWATALARRVAAELQAAAAELRSLPGLPPATAPLLARLLALCPGGPGGLGDPLRALLLLKALQGLRVEWRGRDPRGPGRAQRSAGATAADGPCALRELSVDLRAERSVLIPETYQANNCQGVCGWPQSDRNPRYGNHVVLLLKMQARGAALARPPCCVPTAYAGKLLISLSEERISAHHVPNMVATECGCR |
Position of mature hormone in Pre-Hormone protein | 535 Residues from position (26-560) |
Receptor | Q16671
Detail in HMRbase |
Gene ID | N/A |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11362 |
Swiss-prot Accession number | P04090 (Sequence in FASTA format) |
Description | Prorelaxin H2 precursor [Contains: Relaxin B chain; Relaxin A chain]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the insulin family. |
Tissue Specificity | Isoform 1 expressed in the ovary during pregnancy. Also expressed in placenta, decidua and prostate. Isoform 2 relatively abundant in placenta, much lower abundance in the prostate gland. Not detected in the ovary |
Post translational modification | N/A |
Function | Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix |
Protein Length | 185 Amino acids |
Molecular weight | 21043 |
References | 1 PubMed abstract 6548702 2 PubMed abstract 15164053 3 PubMed abstract 15489334 4 PubMed abstract 8735594 5 PubMed abstract 10601981 6 PubMed abstract 1572287 7 PubMed abstract 2076464 8 PubMed abstract 2040595 9 PubMed abstract 1656049 |
Domain Name | Insulin |
Hormone Name | Relaxin B chain |
Mature Hormone Sequence | DSWMEEVIKLCGRELVRAQIAICGMSTWS |
Position of mature hormone in Pre-Hormone protein | 29 Residues from position (25-53) |
Receptor | Q9HBX9 Detail in HMRbase Q8WXD0 Detail in HMRbase |
Gene ID | 6019 |
PDB ID | 6RLX |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11363 |
Swiss-prot Accession number | P04090 (Sequence in FASTA format) |
Description | Prorelaxin H2 precursor [Contains: Relaxin B chain; Relaxin A chain]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the insulin family. |
Tissue Specificity | Isoform 1 expressed in the ovary during pregnancy. Also expressed in placenta, decidua and prostate. Isoform 2 relatively abundant in placenta, much lower abundance in the prostate gland. Not detected in the ovary |
Post translational modification | N/A |
Function | Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix |
Protein Length | 185 Amino acids |
Molecular weight | 21043 |
References | 1 PubMed abstract 6548702 2 PubMed abstract 15164053 3 PubMed abstract 15489334 4 PubMed abstract 8735594 5 PubMed abstract 10601981 6 PubMed abstract 1572287 7 PubMed abstract 2076464 8 PubMed abstract 2040595 9 PubMed abstract 1656049 |
Domain Name | Insulin |
Hormone Name | Relaxin A chain |
Mature Hormone Sequence | QLYSALANKCCHVGCTKRSLARFC |
Position of mature hormone in Pre-Hormone protein | 24 Residues from position (162-185) |
Receptor | Q9HBX9 Detail in HMRbase Q8WXD0 Detail in HMRbase |
Gene ID | 6019 |
PDB ID | 6RLX |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11369 |
Swiss-prot Accession number | P04808 (Sequence in FASTA format) |
Description | Prorelaxin H1 precursor [Contains: Relaxin B chain; Relaxin A chain]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the insulin family. |
Tissue Specificity | Prostate. Not expressed in placenta, decidua or ovary |
Post translational modification | N/A |
Function | Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix |
Protein Length | 185 Amino acids |
Molecular weight | 21146 |
References | 1 PubMed abstract 6548702 2 PubMed abstract 6298628 3 PubMed abstract 15164053 4 PubMed abstract 15489334 5 PubMed abstract 8735594 6 PubMed abstract 10601981 |
Domain Name | Insulin |
Hormone Name | Relaxin B chain |
Mature Hormone Sequence | VAAKWKDDVIKLCGRELVRAQIAICGMSTWS |
Position of mature hormone in Pre-Hormone protein | 31 Residues from position (23-53) |
Receptor | Q9HBX9 Detail in HMRbase Q8WXD0 Detail in HMRbase |
Gene ID | 6013 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11370 |
Swiss-prot Accession number | P04808 (Sequence in FASTA format) |
Description | Prorelaxin H1 precursor [Contains: Relaxin B chain; Relaxin A chain]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the insulin family. |
Tissue Specificity | Prostate. Not expressed in placenta, decidua or ovary |
Post translational modification | N/A |
Function | Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix |
Protein Length | 185 Amino acids |
Molecular weight | 21146 |
References | 1 PubMed abstract 6548702 2 PubMed abstract 6298628 3 PubMed abstract 15164053 4 PubMed abstract 15489334 5 PubMed abstract 8735594 6 PubMed abstract 10601981 |
Domain Name | Insulin |
Hormone Name | Relaxin A chain |
Mature Hormone Sequence | PYVALFEKCCLIGCTKRSLAKYC |
Position of mature hormone in Pre-Hormone protein | 23 Residues from position (163-185) |
Receptor | Q9HBX9 Detail in HMRbase Q8WXD0 Detail in HMRbase |
Gene ID | 6013 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11372 |
Swiss-prot Accession number | P06307 (Sequence in FASTA format) |
Description | Cholecystokinins precursor (CCK) [Contains: Cholecystokinin 58(CCK58); Cholecystokinin 39 (CCK39); Cholecystokinin 33 (CCK33);Cholecystokinin 12 (CCK12); Cholecystokinin 8 (CCK8)]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the gastrin/cholecystokinin family. |
Tissue Specificity | N/A |
Post translational modification | The precursor cleaved by enzymes to produce a number of active cholecystokinins. |
Function | This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion |
Protein Length | 115 Amino acids |
Molecular weight | 12669 |
References | 1 PubMed abstract 3856870 2 Kato K., Takahashi Y., Matsubara K.; "Molecular cloning of the human cholecystokinin gene."; Ann. N. Y. Acad. Sci. 448:613-615(1985). 3 Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 4 Livingston R.J., Rieder M.J., Chung M.-W., Ritchie T.K., Olson A.N.,Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D., Schackwitz W.S.,Sherwood J.K., Sherwood A.M., Leithauser B.J., Nickerson D.A.; "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Departmentof Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)."; Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. 5 PubMed abstract 15489334 6 PubMed abstract 11076522 |
Domain Name | Gastrin |
Hormone Name | Cholecystokinin |
Mature Hormone Sequence | QPVPPADPAGSGLQRAEEAPRRQLRVSQRTDGESRAHLGALLARYIQQARKAPSGRMSIVKNLQNLDPSHRISDRDYMGWMDFGRRSAEEYEYPS |
Position of mature hormone in Pre-Hormone protein | 95 Residues from position (21-115) |
Receptor | P32239 Detail in HMRbase P32238 Detail in HMRbase |
Gene ID | 885 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11373 |
Swiss-prot Accession number | P06307 (Sequence in FASTA format) |
Description | Cholecystokinins precursor (CCK) [Contains: Cholecystokinin 58(CCK58); Cholecystokinin 39 (CCK39); Cholecystokinin 33 (CCK33);Cholecystokinin 12 (CCK12); Cholecystokinin 8 (CCK8)]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the gastrin/cholecystokinin family. |
Tissue Specificity | N/A |
Post translational modification | The precursor cleaved by enzymes to produce a number of active cholecystokinins. |
Function | This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion |
Protein Length | 115 Amino acids |
Molecular weight | 12669 |
References | 1 PubMed abstract 3856870 2 Kato K., Takahashi Y., Matsubara K.; "Molecular cloning of the human cholecystokinin gene."; Ann. N. Y. Acad. Sci. 448:613-615(1985). 3 Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 4 Livingston R.J., Rieder M.J., Chung M.-W., Ritchie T.K., Olson A.N.,Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D., Schackwitz W.S.,Sherwood J.K., Sherwood A.M., Leithauser B.J., Nickerson D.A.; "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Departmentof Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)."; Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. 5 PubMed abstract 15489334 6 PubMed abstract 11076522 |
Domain Name | Gastrin |
Hormone Name | Cholecystokinin-58 |
Mature Hormone Sequence | VSQRTDGESRAHLGALLARYIQQARKAPSGRMSIVKNLQNLDPSHRISDRDYMGWMDF |
Position of mature hormone in Pre-Hormone protein | 58 Residues from position (46-103) |
Receptor | P32239 Detail in HMRbase P32238 Detail in HMRbase |
Gene ID | 885 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11374 |
Swiss-prot Accession number | P06307 (Sequence in FASTA format) |
Description | Cholecystokinins precursor (CCK) [Contains: Cholecystokinin 58(CCK58); Cholecystokinin 39 (CCK39); Cholecystokinin 33 (CCK33);Cholecystokinin 12 (CCK12); Cholecystokinin 8 (CCK8)]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the gastrin/cholecystokinin family. |
Tissue Specificity | N/A |
Post translational modification | The precursor cleaved by enzymes to produce a number of active cholecystokinins. |
Function | This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion |
Protein Length | 115 Amino acids |
Molecular weight | 12669 |
References | 1 PubMed abstract 3856870 2 Kato K., Takahashi Y., Matsubara K.; "Molecular cloning of the human cholecystokinin gene."; Ann. N. Y. Acad. Sci. 448:613-615(1985). 3 Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 4 Livingston R.J., Rieder M.J., Chung M.-W., Ritchie T.K., Olson A.N.,Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D., Schackwitz W.S.,Sherwood J.K., Sherwood A.M., Leithauser B.J., Nickerson D.A.; "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Departmentof Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)."; Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. 5 PubMed abstract 15489334 6 PubMed abstract 11076522 |
Domain Name | Gastrin |
Hormone Name | Cholecystokinin-39 |
Mature Hormone Sequence | YIQQARKAPSGRMSIVKNLQNLDPSHRISDRDYMGWMDF |
Position of mature hormone in Pre-Hormone protein | 39 Residues from position (65-103) |
Receptor | P32239 Detail in HMRbase P32238 Detail in HMRbase |
Gene ID | 885 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11375 |
Swiss-prot Accession number | P06307 (Sequence in FASTA format) |
Description | Cholecystokinins precursor (CCK) [Contains: Cholecystokinin 58(CCK58); Cholecystokinin 39 (CCK39); Cholecystokinin 33 (CCK33);Cholecystokinin 12 (CCK12); Cholecystokinin 8 (CCK8)]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the gastrin/cholecystokinin family. |
Tissue Specificity | N/A |
Post translational modification | The precursor cleaved by enzymes to produce a number of active cholecystokinins. |
Function | This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion |
Protein Length | 115 Amino acids |
Molecular weight | 12669 |
References | 1 PubMed abstract 3856870 2 Kato K., Takahashi Y., Matsubara K.; "Molecular cloning of the human cholecystokinin gene."; Ann. N. Y. Acad. Sci. 448:613-615(1985). 3 Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 4 Livingston R.J., Rieder M.J., Chung M.-W., Ritchie T.K., Olson A.N.,Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D., Schackwitz W.S.,Sherwood J.K., Sherwood A.M., Leithauser B.J., Nickerson D.A.; "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Departmentof Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)."; Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. 5 PubMed abstract 15489334 6 PubMed abstract 11076522 |
Domain Name | Gastrin |
Hormone Name | Cholecystokinin-33 |
Mature Hormone Sequence | KAPSGRMSIVKNLQNLDPSHRISDRDYMGWMDF |
Position of mature hormone in Pre-Hormone protein | 33 Residues from position (71-103) |
Receptor | P32239 Detail in HMRbase P32238 Detail in HMRbase |
Gene ID | 885 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11376 |
Swiss-prot Accession number | P06307 (Sequence in FASTA format) |
Description | Cholecystokinins precursor (CCK) [Contains: Cholecystokinin 58(CCK58); Cholecystokinin 39 (CCK39); Cholecystokinin 33 (CCK33);Cholecystokinin 12 (CCK12); Cholecystokinin 8 (CCK8)]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the gastrin/cholecystokinin family. |
Tissue Specificity | N/A |
Post translational modification | The precursor cleaved by enzymes to produce a number of active cholecystokinins. |
Function | This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion |
Protein Length | 115 Amino acids |
Molecular weight | 12669 |
References | 1 PubMed abstract 3856870 2 Kato K., Takahashi Y., Matsubara K.; "Molecular cloning of the human cholecystokinin gene."; Ann. N. Y. Acad. Sci. 448:613-615(1985). 3 Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 4 Livingston R.J., Rieder M.J., Chung M.-W., Ritchie T.K., Olson A.N.,Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D., Schackwitz W.S.,Sherwood J.K., Sherwood A.M., Leithauser B.J., Nickerson D.A.; "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Departmentof Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)."; Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. 5 PubMed abstract 15489334 6 PubMed abstract 11076522 |
Domain Name | Gastrin |
Hormone Name | Cholecystokinin-8 |
Mature Hormone Sequence | DYMGWMDF |
Position of mature hormone in Pre-Hormone protein | 8 Residues from position (96-103) |
Receptor | P32239 Detail in HMRbase P32238 Detail in HMRbase |
Gene ID | 885 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11377 |
Swiss-prot Accession number | P06850 (Sequence in FASTA format) |
Description | Corticoliberin precursor (Corticotropin-releasing factor) (CRF)(Corticotropin-releasing hormone). |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted protein |
Developmental Stage | N/A |
Similarity | Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | This hormone from hypothalamus regulates the release of corticotropin from pituitary gland |
Protein Length | 196 Amino acids |
Molecular weight | 21422 |
References | 1 PubMed abstract 6605851 2 PubMed abstract 2783917 3 Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 4 PubMed abstract 15489334 5 PubMed abstract 3262120 6 PubMed abstract 8386360 |
Domain Name | CRF |
Hormone Name | Corticoliberin |
Mature Hormone Sequence | SEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEII |
Position of mature hormone in Pre-Hormone protein | 41 Residues from position (154-194) |
Receptor | P34998 Detail in HMRbase Q13324 Detail in HMRbase |
Gene ID | 1392 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11387 |
Swiss-prot Accession number | P07492 (Sequence in FASTA format) |
Description | Gastrin-releasing peptide precursor (GRP) [Contains: Neuromedin-C(GRP-10)]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the bombesin/neuromedin-B/ranatensin family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | GRP stimulates gastrin release as well as other gastrointestinal hormones |
Protein Length | 148 Amino acids |
Molecular weight | 16144 |
References | 1 PubMed abstract 3001723 2 PubMed abstract 3211139 3 PubMed abstract 3003116 4 PubMed abstract 15489334 |
Domain Name | Bombesin |
Hormone Name | Gastrin-releasing peptide |
Mature Hormone Sequence | VPLPAGGGTVLTKMYPRGNHWAVGHLM |
Position of mature hormone in Pre-Hormone protein | 27 Residues from position (24-50) |
Receptor | P30550
Detail in HMRbase |
Gene ID | 2922 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11388 |
Swiss-prot Accession number | P07492 (Sequence in FASTA format) |
Description | Gastrin-releasing peptide precursor (GRP) [Contains: Neuromedin-C(GRP-10)]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the bombesin/neuromedin-B/ranatensin family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | It is also a bombesin-like peptide, which causes potent stimulation of smooth muscle of uterus. |
Protein Length | 148 Amino acids |
Molecular weight | 16144 |
References | 1 PubMed abstract 3001723 2 PubMed abstract 3211139 3 PubMed abstract 3003116 4 PubMed abstract 15489334 |
Domain Name | Bombesin |
Hormone Name | Neuromedin-C |
Mature Hormone Sequence | GNHWAVGHLM |
Position of mature hormone in Pre-Hormone protein | 10 Residues from position (41-50) |
Receptor | P30550
Detail in HMRbase |
Gene ID | 2922 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11396 |
Swiss-prot Accession number | P09683 (Sequence in FASTA format) |
Description | Secretin precursor. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the glucagon family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach |
Protein Length | 121 Amino acids |
Molecular weight | 13016 |
References | 1 PubMed abstract 11060443 2 Carlquist M., Joernvall H., Forssmann W.-G., Thulin L., Johansson C.,Mutt V.; "Human secretin is not identical to the porcine/bovine hormone."; IRCS Med. Sci. 13:217-218(1985). |
Domain Name | Hormone_2 |
Hormone Name | Secretin |
Mature Hormone Sequence | HSDGTFTSELSRLREGARLQRLLQGLV |
Position of mature hormone in Pre-Hormone protein | 27 Residues from position (28-54) |
Receptor | Q8IV17 Detail in HMRbase P47872 Detail in HMRbase |
Gene ID | 6343 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11423 |
Swiss-prot Accession number | P20382 (Sequence in FASTA format) |
Description | Pro-MCH precursor [Contains: Neuropeptide-glycine-glutamic acid (NGE)(Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine (NEI)(Neuropeptide E-I); Melanin-concentrating hormone (MCH)]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted protein |
Developmental Stage | N/A |
Similarity | Belongs to the melanin-concentrating hormone family. |
Tissue Specificity | Predominantly expressed in lateral hypothalamus, also detected in pallidum, neocortex and cerebellum. Also found in thymus, brown adipose tissue, duodenum and testis (spermatogonia, early spermatocytes and Sertoli cells). No expression in peripheral blood. In brain exclusively mature MCH and NEI peptides are present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly |
Post translational modification | Differentially processed in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6. MCH is a cyclic peptide. |
Function | N/A |
Protein Length | 165 Amino acids |
Molecular weight | 18723 |
References | 1 PubMed abstract 2149166 2 PubMed abstract 8326825 3 PubMed abstract 10037747 4 PubMed abstract 9191099 |
Domain Name | Pro-MCH |
Hormone Name | Neuropeptide-glutamic acid-isoleucine |
Mature Hormone Sequence | EIGDEENSAKFPI |
Position of mature hormone in Pre-Hormone protein | 13 Residues from position (131-143) |
Receptor | Q99705 Detail in HMRbase Q969V1 Detail in HMRbase |
Gene ID | N/A |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11424 |
Swiss-prot Accession number | P20382 (Sequence in FASTA format) |
Description | Pro-MCH precursor [Contains: Neuropeptide-glycine-glutamic acid (NGE)(Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine (NEI)(Neuropeptide E-I); Melanin-concentrating hormone (MCH)]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted protein |
Developmental Stage | N/A |
Similarity | Belongs to the melanin-concentrating hormone family. |
Tissue Specificity | Predominantly expressed in lateral hypothalamus, also detected in pallidum, neocortex and cerebellum. Also found in thymus, brown adipose tissue, duodenum and testis (spermatogonia, early spermatocytes and Sertoli cells). No expression in peripheral blood. In brain exclusively mature MCH and NEI peptides are present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly |
Post translational modification | Differentially processed in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6. MCH is a cyclic peptide. |
Function | MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation |
Protein Length | 165 Amino acids |
Molecular weight | 18723 |
References | 1 PubMed abstract 2149166 2 PubMed abstract 8326825 3 PubMed abstract 10037747 4 PubMed abstract 9191099 |
Domain Name | Pro-MCH |
Hormone Name | Melanin-concentrating hormone |
Mature Hormone Sequence | FPIGRRDFDMLRCMLGRVYRPCWQV |
Position of mature hormone in Pre-Hormone protein | 19 Residues from position (147-165) |
Receptor | Q99705 Detail in HMRbase Q969V1 Detail in HMRbase |
Gene ID | N/A |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11425 |
Swiss-prot Accession number | P20396 (Sequence in FASTA format) |
Description | Thyroliberin precursor [Contains: Prothyroliberin; Thyroliberin(Thyrotropin-releasing hormone) (TRH) (Thyrotropin-releasing factor)(TRF) (TSH-releasing factor) (Protirelin)]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted protein |
Developmental Stage | N/A |
Similarity | Belongs to the TRH family. |
Tissue Specificity | Hypothalamus |
Post translational modification | N/A |
Function | Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems |
Protein Length | 242 Amino acids |
Molecular weight | 27404 |
References | 1 PubMed abstract 2126343 2 PubMed abstract 15489334 |
Domain Name | TRH |
Hormone Name | Thyroliberin |
Mature Hormone Sequence | QHP |
Position of mature hormone in Pre-Hormone protein | 3 Residues from position (84-86) |
Receptor | P34981
Detail in HMRbase |
Gene ID | 7200 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11489 |
Swiss-prot Accession number | P61278 (Sequence in FASTA format) |
Description | Somatostatin precursor (Growth hormone release-inhibiting factor)[Contains: Somatostatin-28; Somatostatin-14]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the somatostatin family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Somatostatin inhibits the release of somatotropin |
Protein Length | 116 Amino acids |
Molecular weight | 12736 |
References | 1 PubMed abstract 6126875 2 PubMed abstract 6142531 3 PubMed abstract 15489334 4 PubMed abstract 6126875 5 PubMed abstract 6142531 6 PubMed abstract 15489334 |
Domain Name | Somatostatin |
Hormone Name | Somatostatin-28 |
Mature Hormone Sequence | SANSNPAMAPRERKAGCKNFFWKTFTSC |
Position of mature hormone in Pre-Hormone protein | 28 Residues from position (89-116) |
Receptor | P30872 Detail in HMRbase P30874 Detail in HMRbase P32745 Detail in HMRbase P35346 Detail in HMRbase |
Gene ID | 6750 |
PDB ID | 1P2W |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11490 |
Swiss-prot Accession number | P61278 (Sequence in FASTA format) |
Description | Somatostatin precursor (Growth hormone release-inhibiting factor)[Contains: Somatostatin-28; Somatostatin-14]. |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the somatostatin family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Somatostatin inhibits the release of somatotropin |
Protein Length | 116 Amino acids |
Molecular weight | 12736 |
References | 1 PubMed abstract 6126875 2 PubMed abstract 6142531 3 PubMed abstract 15489334 4 PubMed abstract 6126875 5 PubMed abstract 6142531 6 PubMed abstract 15489334 |
Domain Name | Somatostatin |
Hormone Name | Somatostatin-14 |
Mature Hormone Sequence | AGCKNFFWKTFTSC |
Position of mature hormone in Pre-Hormone protein | 14 Residues from position (103-116) |
Receptor | P30872 Detail in HMRbase P30874 Detail in HMRbase P32745 Detail in HMRbase P35346 Detail in HMRbase |
Gene ID | 6750 |
PDB ID | 1P2W |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11506 |
Swiss-prot Accession number | Q86YW7 (Sequence in FASTA format) |
Description | Glycoprotein hormone beta-5 precursor (Thyrostimulin subunit beta). |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted protein |
Developmental Stage | N/A |
Similarity | Belongs to the glycoprotein hormones subunit beta family. |
Tissue Specificity | Highly expressed in brain and at low levels in pituitary. Also found in retina, testis and skin but not in pancreas, parotid, kidney, stomach, liver, colon, small intestine, thyroid, brain or adrenal gland. In pituitary, colocalizes with ACTH, suggesting that it is located in corticotrophs |
Post translational modification | N-glycosylated. |
Function | Stimulates the thyroid. Binds and activates THSR, leading to increased cAMP production |
Protein Length | 130 Amino acids |
Molecular weight | 14232 |
References | 1 PubMed abstract 12045258 2 Holloway J.L., O'Hogan S.L., Tackett M., Taft D., Thayer E.C.,Webster P.; "A novel glycoprotein hormone beta subunit."; Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases. 3 PubMed abstract 12508121 4 PubMed abstract 15489334 5 PubMed abstract 12089349 6 PubMed abstract 16210345 |
Domain Name | Cys_knot |
Hormone Name | Glycoprotein hormone beta-5 |
Mature Hormone Sequence | ASSGNLRTFVGCAVREFTFLAKKPGCRGLRITTDACWGRCETWEKPILEPPYIEAHHRVCTYNETKQVTVKLPNCAPGVDPFYTYPVAIRCDCGACSTATTECETI |
Position of mature hormone in Pre-Hormone protein | 106 Residues from position (25-130) |
Receptor | P16473
Detail in HMRbase |
Gene ID | 122876 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11531 |
Swiss-prot Accession number | P41159 (Sequence in FASTA format) |
Description | Leptin;Alternative Name: Obesity factor;Alternative Name: Obese protein; Precursor |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the leptin family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass. |
Protein Length | 167 Amino acids |
Molecular weight | 18641 |
References | 1 PubMed abstract 7984236 2 PubMed abstract 7789654 3 PubMed abstract 8626726 4 PubMed abstract 7499240 5 PubMed abstract 8621021 6 PubMed abstract 15489334 7 PubMed abstract 10428856 8 PubMed abstract 9166907 9 PubMed abstract 9144295 10 PubMed abstract 9500540 |
Domain Name | Leptin |
Hormone Name | Leptin |
Mature Hormone Sequence | |
Position of mature hormone in Pre-Hormone protein | |
Receptor | P48357 Detail in HMRbase O95214 Detail in HMRbase O15243 Detail in HMRbase A8K2E3 Detail in HMRbase Q6FHL5 Detail in HMRbase Q6FHL7 Detail in HMRbase |
Gene ID | 3952 |
PDB ID | 1AX8 |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11544 |
Swiss-prot Accession number | A4D0Y8 (Sequence in FASTA format) |
Description | Leptin (Obesity homolog, mouse) |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | N/A |
Developmental Stage | N/A |
Similarity | N/A |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | N/A |
Protein Length | 167 Amino acids |
Molecular weight | 18641 |
References | 1 PubMed abstract 12690205 |
Domain Name | Leptin |
Hormone Name | Leptin |
Mature Hormone Sequence | |
Position of mature hormone in Pre-Hormone protein | |
Receptor | P48357 Detail in HMRbase O95214 Detail in HMRbase O15243 Detail in HMRbase A8K2E3 Detail in HMRbase Q6FHL5 Detail in HMRbase Q6FHL7 Detail in HMRbase |
Gene ID | 3952 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11545 |
Swiss-prot Accession number | B2R8Y2 (Sequence in FASTA format) |
Description | cDNA, FLJ94114, highly similar to Homo sapiens leptin (obesity homolog, mouse) (LEP), mRNA |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | N/A |
Developmental Stage | N/A |
Similarity | N/A |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | N/A |
Protein Length | 167 Amino acids |
Molecular weight | 18624 |
References | ---- |
Domain Name | Leptin |
Hormone Name | Leptin |
Mature Hormone Sequence | |
Position of mature hormone in Pre-Hormone protein | |
Receptor | P48357 Detail in HMRbase O95214 Detail in HMRbase O15243 Detail in HMRbase A8K2E3 Detail in HMRbase Q6FHL5 Detail in HMRbase Q6FHL7 Detail in HMRbase |
Gene ID | N/A |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11546 |
Swiss-prot Accession number | Q6NT58 (Sequence in FASTA format) |
Description | Leptin |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | N/A |
Developmental Stage | N/A |
Similarity | N/A |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | N/A |
Protein Length | 167 Amino acids |
Molecular weight | 18613 |
References | 1 PubMed abstract 15489334 |
Domain Name | Leptin |
Hormone Name | Leptin |
Mature Hormone Sequence | |
Position of mature hormone in Pre-Hormone protein | |
Receptor | P48357 Detail in HMRbase O95214 Detail in HMRbase O15243 Detail in HMRbase A8K2E3 Detail in HMRbase Q6FHL5 Detail in HMRbase Q6FHL7 Detail in HMRbase |
Gene ID | N/A |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11575 |
Swiss-prot Accession number | P00797 (Sequence in FASTA format) |
Description | Renin; EC=3.4.23.15;Alternative Name: Angiotensinogenase;Precursor |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Secreted. Membrane. Note=Associated to membranes via binding to ATP6AP2 |
Developmental Stage | N/A |
Similarity | Belongs to the peptidase A1 family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. |
Protein Length | 406 Amino acids |
Molecular weight | 45057 |
References | 1 PubMed abstract 6324167 2 PubMed abstract 3530608 3 PubMed abstract 6391881 4 PubMed abstract 16710414 5 PubMed abstract 15489334 6 PubMed abstract 6138751 7 PubMed abstract 3032746 8 PubMed abstract 2540188 9 PubMed abstract 3516796 10 PubMed abstract 2016271 11 PubMed abstract 12045255 12 PubMed abstract 2493678 13 PubMed abstract 1608447 14 PubMed abstract 16116425 |
Domain Name | A1_Propeptide Asp |
Hormone Name | Renin |
Mature Hormone Sequence | |
Position of mature hormone in Pre-Hormone protein | |
Receptor | O75787 Detail in HMRbase |
Gene ID | 5972 |
PDB ID | 1BBS 1BIL 1BIM 1HRN 1RNE 2BKS 2BKT 2FS4 2G1N 2G1O 2G1R 2G1S 2G1Y 2G20 2G21 2G22 2G24 2G26 2G27 2I4Q 2IKO 2IKU 2IL2 2REN 2V0Z 2V10 2V11 2V12 2V13 2V16 3D91 |
Drugpedia | wiki |
Comments |
HMRbase accession number | 11581 |
Swiss-prot Accession number | Q6FI38 (Sequence in FASTA format) |
Description | REN protein;Renin |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | N/A |
Developmental Stage | N/A |
Similarity | Belongs to the peptidase A1 family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | N/A |
Protein Length | 406 Amino acids |
Molecular weight | 45057 |
References | ---- |
Domain Name | A1_Propeptide Asp |
Hormone Name | Renin |
Mature Hormone Sequence | |
Position of mature hormone in Pre-Hormone protein | |
Receptor | O75787 Detail in HMRbase |
Gene ID | 5972 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |